TEMPORAL BIOMECHANICS OF HEALING IN SPINAL INJURIES

脊柱创伤是致残损伤的主要原因。治疗方法 这些损伤与相关的神经学因素有关 以及脊椎是否被视为“不稳定”。多数 通常，治疗取决于后一点。尽管这些是一些 文献中公认的评估临床不稳定性的标准， 它们只适用于急性评估，不考虑正在进行的生物学评估。 愈合和适应的过程。因此，目前我们没有能力 评估延缓稳定或不稳定的时间进程。 我们建议研究颈椎损伤的愈合作为一种 时间函数，长达六个月，采用犬科动物模型。离体 首先将确定“稳定”和“不稳定”伤害的定义。 这些信息随后将用于活体模型，以产生三个 伤情严重程度不一，而且是假的。也是在手术的时候， 将三个0.8 mm钢球植入损伤部位的椎体内 上下各有一块椎骨。使用立体声技术 X线摄影和计算机数字化，颈椎的精确分析 运动将在活体内进行，同时发生愈合。三维 损伤和假损伤的稳定性分析及强度测量 脊椎将在牺牲后在标本中进行制作。 除了单独分析每个数据集之外，与其他数据的相关性 还将获得类型。体内稳定性测试将提供 连续的生物力学信息关于愈合过程的一个和 同样的动物。这将产生更好的临床相关标准。 关于脊柱不稳的定义。体外实验中的密切相关 体内稳定性结果可能会提供一种监测骨盆骨折愈合的方法 脊椎结构。最后，功能脊柱单位和个人韧带 强度分析将产生有关脊柱变化的数据 作为脊柱损伤的功能的组成部分，例如脊椎和韧带 治愈时间到了。

Trauma of the spine is a major cause of disabling injuries. The treatment of these injuries is dependent upon such factors as associated neurological injuries and whether or not the spine is considered "unstable". Most often, the treatment hinges on this latter point. Although these are some accepted criteria in the literature for assessment of clinical instability, they apply only to acute evaluation and do not consider ongoing biological processes of healing and adaptation. Thus, presently we have no ability to assess temporal progression either towards delayed stability or instability. We propose to investigate the healing of injury to the cervical spine as a function of time, up to six months, using a canine model. In vitro definition of "stable" and "unstable" injuries will first be established. This information will then be used in an in vivo model to produce three injuries of varying severity and a sham. Also at the time of surgery, three 0.8 mm steel ball will be implanted into vertebrae at the injury site and one vertebrae above and below it. Using the techniques of stereo radiography and computer digitization, precise analysis of cervical spinal motion will be done in vivo while healing occurs. Three dimensional stability analyses as well as strength measurements of injured and sham spines will be performed in specimens after sacrifice. Besides analyzing each data set individually, correlations with other data types will also be obtained. The in vivo stability testing will provide continuous biomechanical information about the healing process in one and the same animal. This will result in better clinically relevant criteria for the definition of spinal instability. Close correlation of in vitro and in vivo stability results could suggest a method to monitor healing of spinal structures. Finally, functional spinal unit and individual ligament strength analysis will yield data about the changes in the spinal column components, e.g. vertebrae and ligaments, as function of spinal injury and healing time.