LUNG CANCER IN NON-SMOKING WOMEN

这项研究旨在检验非自愿的假设 暴露在烟草烟雾中会增加患肺癌的风险。 不吸烟的女性。这是一项基于人群的病例对照研究。 从未使用过烟草产品并患上肺部疾病的女性 癌症。在五个主要大都市迅速确诊病例 地区：亚特兰大、休斯顿、洛杉矶、新奥尔良和旧金山 旧金山-奥克兰-圣何塞湾区。访谈案例数据 将其与两个参照组进行比较：一组不吸烟 来自同一地理区域的患有结肠癌和 随机数字选择非吸烟人群对照组 拨打和从H.C.F.A.文件中。面谈是在 研究对象或其近亲的家。详细 获得有关非自愿接触烟草烟雾的信息 在童年和成人生活中。此外，市民亦可在 其他肺癌危险因素(潜在混杂因素)，如 职业和行业就业，饮食，居住因素， 特定的呼吸道致癌物质、癌症家族史和 人口统计特征。 尿样和头发样本是从研究中收集的 受试者的可替宁(一种代谢物 尼古丁)含量。执行这些分析是为了验证 受试者关于最近吸烟习惯的报告状态。 氡监测器也会按顺序放置在家里48小时 以确定居民区的氡气水平。为了确保 肺癌的标准化组织学分类， 有关肺癌病例的组织样本，请向 合适的病理科借阅。这些标本来自 然后由一项研究对所有五个城市的患者进行审查 病理学家。 将在分析中使用Logistic回归技术 根据与以下各项相关的组织类型检查肺癌风险 被动吸烟，同时控制混杂变量。

This study is designed to test the hypothesis that involuntary exposure to tobacco smoke increases the risk of lung cancer in non-smoking women. It is a population based case-control study of women who have never used tobacco products and develop lung cancer. Cases are rapidly ascertained in five major metropolitan areas: Atlanta, Houston, Los Angeles, New Orleans and San Francisco-Oakland-San Jose Bay Area. Interview data from cases will be compared to two reference groups: a group of non-smoking women from the same geographic area who have colon cancer and a non-smoking population control group selected by random digit dialing and from H.C.F.A. files. Interviews are conducted in the homes of study subjects or their next-of-kin. Detailed information is obtained on involuntary exposure to tobacco smoke during childhood and adult life. Information is also sought on other lung cancer risk factors (potential confounders) such as occupation and industry of employment, diet, residential factors, specific respiratory carcinogens, family history of cancer and demographic characteristics. Urine specimens and hair samples are collected from study subjects for the analysis of their cotinine (a metabolite of nicotine) content. These analyses are performed to validate the subject's reported status with respect to recent smoking habits. Radon monitors are also placed in the home for 48 hours in order to determine the residential level of radon gas. To ensure standardized histologic classification of lung cancer cased, tissue specimens of lung cancer cases are requested from the appropriate pathology department for loan. These specimens from patients in all five cities are then reviewed by one study pathologist. Logistic regression techniques will be used in the analysis to examine risk of lung cancer by histologic type associated with passive smoking while controlling for confounding variables.