PHYSIOLOGICAL FACTORS IN HYPERTHERMIA

热疗与放疗联合使用，或 化疗正在成为一种既定的治疗方法， 癌症的治疗。 虽然恶性细胞不是 由于肿瘤细胞比正常细胞对热更敏感， 通常比正常组织更容易受热。 是 认为血管结构的内在差异， 以及脉管系统和相关的热响应 肿瘤和正常组织中的生理和代谢因素 是热疗的这种优先效应的主要原因， 肿瘤的 具体来说，肿瘤中的温度往往会升高， 在加热过程中高于邻近正常组织，由于 由于血液流动缓慢， 肿瘤相对于正常组织中。 人们已经知道 哺乳动物细胞的温度敏感性 在酸性和营养不良的条件下增强。 有趣的是， 肿瘤内的环境是酸性的并且缺乏营养。 这种情况可能在加热的肿瘤中进一步增强 由于血管功能和相关的生理生化 有效使用热疗的因素。 的长期 本研究的目的是进一步了解血液的作用， 热疗中的流动和相关微环境 癌症。 本申请的具体目的是阐明本发明的实施例。 正常内脏器官中热诱导的血管变化。 热诱导的皮肤组织血流变化 已经被广泛研究，但是热对血液流动的影响 在其他正常组织中，包括体腔中的器官， 几乎无人知晓 这可能是因为， 还没有合适的设备来加热深层内脏器官， available. 我们最近得到了一个电容加热装置 能够加热实验动物的深层内脏。 我们建议研究热对血液流动的影响， 还确定了血管损伤的阈值热剂量， 大鼠的各种内脏。 将测量血流量 用放射性微球方法， 建立在我们的实验室。 我们坚信 在这项研究中获得的将提供一个合理的基础， 热疗在治疗深部肿瘤中的有效应用 可以计划。

Hyperthermia used in combination with radiotherapy or chemotherapy is becoming an established modality for the treatment of cancer. Although malignant cells are not necessarily more heat-sensitive than normal cells, tumors are generally more vulnerable to heat than are normal tissues. It is believed that the intrinsic difference in the vascular structure as well as the thermal response of vasculature and related physiological and metabolic factors in tumors and normal tissues is the main cause of such preferential effect of hyperthermia on tumors. Specifically, the temperature in tumors tends to rise higher than that in adjacent normal tissues during heating, owing to the inefficient heat dissipation by the sluggish blood flow in the tumors relative to that in the normal tissues. It has been known that the thermosensitivity of mammalian cells is profoundly enhanced by acidic and poor nutritional conditions. Interestingly, the intratumor environment is acidic and nutritionally deprived. This condition is further enhanced in the heated tumor probably due to vascular function and related physiological and biochemical factors for the effective use of hyperthermia. The longterm objective of this sutdy is to further understand the role of blood flow and related microenvironment in the hyperthermic treatment of cancer. The specific aim of this application is to elucidate the heatinduced vascular changes in normal internal organs. The heatedinduced change in blood flow in cutaneous tissue has been extensively studied, but the effect of heat on the blood flow in other normal tissues, including the organs in the body cavity, is virtually unknown. This may be attributed to the fact that a suitable device to heat the deep internal organs has not been available. We recently acquired a capacitive heating device capable of heating deep internal organs of experimental animals. We propose to investigate the effect of heat on the blood flow and also determine the threshold thermal dose for vascular damage in various internal organs of rats. The blood flow will be measured with the radioactive microsphere method, which has long been established in our laboratory. We strongly believe the information obtained in this study will provide a rationale basis on which an effective use of hyperthermia to treat deepseated human tumors can be planned.