A Nano-platform for affordable and ultra-sensitive bio-marker detection

该项目旨在开发下一代纳米平台和横向流动分析（LFA）装置，用于超灵敏的生物标志物检测。LFA用于快速检测生物标志物；但是，它们的灵敏度相对较低。制备具有均匀粒径和可控结构（孔径、孔结构、内表面功能和密度）的新型多孔二氧化硅纳米颗粒将实现更高的量子点负载和更高的检测灵敏度。提高廉价和一次性LFA诊断技术的检测灵敏度将为快速准确的生物标志物检测开辟新的应用。由此产生的技术将提高澳大利亚在全球横向流动分析市场的工业能力和竞争力，预计到2020年该市场的价值将达到67.8亿美元。

This project aims to develop a next-generation nano-platform and lateral flow assays (LFA) device for ultra-sensitive detection of biomarkers. LFA’s are used for the rapid detection of biomarkers; however, their sensitivity is relatively low. The preparation of innovative porous silica nanoparticles with uniform particle size and controllable structures (pore size, pore structure, internal surface functionality and density) will enable higher loading of quantum dots and enhanced detection sensitivity. Improving the detection sensitivity of the inexpensive and disposable LFA diagnostic technology will open up new applications for rapid and accurate biomarker detection. The resulting technology will advance Australian industrial capability and competiveness in the global lateral flow assays market, which is estimated to be valued at US$ 6.78 billion by 2020.