COCAINE & BEHAVIOR: ORAL ABUSE & MOTOR CONTROL

本建议研究口服可卡因的行为药理学。 自治。诱变的最佳条件 用不同的药物建立大鼠可卡因过度沉迷模型 浓度和食物调度诱导参数 都会产生过度的行为。通常的效果是- 使用和滥用合法药物(尼古丁和咖啡因)可能在 增加计划诱导的可卡因摄入量将被确定为 以及有希望的治疗可能的减毒作用 (地昔帕明)和阻断剂(如氯丙嗪和 匹莫齐特)。将对一些商品和活动进行测试 作为可用可卡因的行为替代品 产生过度行为的条件。广泛接触 以前有过使用非药物、高度首选的物质的经验 作为糖精(然后无法获得)在条件下 这应该会导致可卡因滥用，可能会阻碍其发展，因为 可以对诱导条件进行预适应。这种可能性 先前过量摄入尼古丁或咖啡因可能是易感因素 将对可卡因滥用的发展进行探索。的影响 对注射可卡因进行精细运动控制的任务将 以及咖啡因和咖啡因的交互作用 尼古丁与慢性可卡因就有这种表现。血清 可卡因和代谢物水平将与行为相关 效果。

This proposal studies the behavioral pharmacology of oral cocaine self-administration. The optimal conditions for the induction of cocaine overindulgence in rats will be established by varying drug concentration and the food-schedule induction parameters which are known to produce excessive behaviors. The effect commonly- used and abuse licit agents (nicotine and caffeine) might have in increasing schedule-induced cocaine intake will be determined, as well as possible attenuating effects of promising therapeutic (desipramine) and blocking agents (e.g., chlorpromazine and pimozide). A number of commodities and activities will be tested as behavioral alternatives to available cocaine under the excessive-behavior-generating conditions. Extensive exposure to prior experiences with non-drug, highly-preferred substances such as saccharin (which are then made unavailable) under conditions that should induce cocaine abuse may block its development, as may pre-adaptation to the inducing conditions. The possibility that prior overindulgence of nicotine or caffeine may predispose to cocaine abuse development will be explored. The effect of parenteral cocaine injection on a fine motor control task will be determined, as well as the interactive effects of caffeine and of nicotine with chronic cocaine on this kind of performance. Serum cocaine and metabolite levels will be correlated with behavioral effects.