SYNTHETIC MODELS FOR HEMOCYANIN

提出了将综合模型法应用于含氧 蛋白质，血蓝蛋白，以获得基本的理解， 活性部位化学 合成化学包括制备 新的苯并咪唑螯合配体， 类似于为各国设想的结构， 血蓝蛋白 在完成了对类似物的详细研究之后， 高铁血蓝蛋白的注意力现在将集中在更具挑战性的 氧合血蓝蛋白的问题 重点将放在明确的 用X射线晶体学表征晶体材料， 光谱方法（IR、ESR、UV-VIS、共振拉曼）。 化合物 将提供定义良好的系统，以测试最近的有效性 电子，振动和EXAFS光谱应用于血蓝蛋白。 长期目标是了解化学， 铜蛋白的生物化学，特别是具有铜/双氧的那些 交互. 铜蛋白分子水平的研究进展 必须成为治疗疾病的医学方法的基础， 铜（例如，威尔逊氏病）或使用铜螯合物的疗法（例如， 抗关节炎剂、抗肿瘤剂）。

It is proposed to apply the synthetic model approach to the oxygen-carying protein, hemocyanin, in order to gain an understanding of the fundamental active site chemistry. The synthetic chemistry involves the preparation of new benzimidazole chelating ligands which can hold copper ions in structures similar to those envisaged for the various states of hemocyanin. Having completed a detailed study of analogues of met-hemocyanin attention will now be focused on the more challenging problem of oxyhemocyanin. Emphasis will be placed on definitive characterization of crystalline materials by x-ray crystallography and spectroscopic methods (IR, ESR, UV-VIS, Resonance Raman). The compounds will provide well-defined systems on which to test the validity of recent electronic, vibrational and EXAFS spectroscopy applications to hemocyanin. The long term goal is to gain an understanding of the chemistry and biochemistry of copper proteins, particularly those having copper/dioxygen interactions. A detailed molecular level undertanding of copper proteins must underlie medical approaches to the therapy of disorders involving copper (e.g., Wilson's disease) or therapies using copper chelates (e.g., antiarthritic, antitumor agents).