PHARMACOLOGY OF ANTIRHEUMATIC AGENTS
PHARMACOLOGY OF ANTIRHEUMATIC AGENTS
批准号:
6246913
负责人:
BRUCE Neil CRONSTEIN
金额:
$2.39万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-02-12 至 1997-11-30
关键词:
adenosine antiinflammatory agents biological signal transduction clinical research clinical trials drug screening /evaluation enzyme linked immunosorbent assay human subject human therapy evaluation methotrexate northern blottings nucleic acid chemical synthesis polymerase chain reaction rheumatoid arthritis skeletal disorder chemotherapy skeletal pharmacology sulfanilamides
中文摘要
这项研究表明,在活体模型和患者中
类风湿性关节炎抗炎药物的作用,特别是
甲氨蝶呤和柳氮磺吡啶,是由于它们的容量增加
胞外腺苷。调查人员得出结论,这一信号
腺苷的转导通过一种新的途径进行。实验室被用来
用于:EL ISA、寡核苷酸合成Northern分析和
聚合酶链式反应。
英文摘要
This study demonstrates that in in vivo models and patients with
rheumatoid arthritis the effects of antiinflammatory drugs, specifically
methotrexate and sulfasalzine, are due to their capacity to increase
extracellular adenosine. The investigators have concluded that signal
transduction of adenosine proceeds by a novel pathway. The lab was used
for the following: ELISA, oligonucleotide synthesis Northern analysis and
PCR.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Clinical and Translational Science Award
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批准号:10255087
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项目类别:
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资助金额:$2.53万
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财政年份:2020
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负责人:BRUCE Neil CRONSTEIN
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依托单位:
Engineering Personalized Devices for Craniomaxillofacial Defects
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批准号:10116988
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项目类别:
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资助金额:$38.58万
-
财政年份:2019
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负责人:BRUCE Neil CRONSTEIN
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依托单位:
Clinical and Translational Science Award
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批准号:10183901
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项目类别:
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资助金额:$76.85万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
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依托单位:
Clinical and Translational Science Award
-
批准号:10320492
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项目类别:
-
资助金额:$853.49万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Clinical and Translational Science Award
-
批准号:10317650
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项目类别:
-
资助金额:$2034.35万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Clinical and Translational Science Award
-
批准号:9085750
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项目类别:
-
资助金额:$489.41万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
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依托单位:
Clinical and Translational Science Award
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批准号:10289909
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项目类别:
-
资助金额:$827.88万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
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依托单位:
Clinical and Translational Science Award
-
批准号:10310799
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项目类别:
-
资助金额:$1098.19万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Clinical and Translational Science Award
-
批准号:9252686
-
项目类别:
-
资助金额:$14.65万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Clinical and Translational Science Award
-
批准号:10382896
-
项目类别:
-
资助金额:$13.68万
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财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Purinergic Stimulation of Bone Regeneration
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批准号:9269987
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项目类别:
-
资助金额:$53.64万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Clinical and Translational Science Award
-
批准号:9562467
-
项目类别:
-
资助金额:$38.5万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Clinical and Translational Science Award
-
批准号:10174469
-
项目类别:
-
资助金额:$221.84万
-
财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Purinergic Stimulation of Bone Regeneration
-
批准号:8953230
-
项目类别:
-
资助金额:$58.29万
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财政年份:2015
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
Institutional Clinical and Translational Science Award
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批准号:8776084
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项目类别:
-
资助金额:$230.91万
-
财政年份:2014
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负责人:BRUCE Neil CRONSTEIN
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依托单位:
Institutional Clinical and Translational Science Award
-
批准号:8776062
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项目类别:
-
资助金额:$11.03万
-
财政年份:2014
-
负责人:BRUCE Neil CRONSTEIN
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依托单位:
Purinergic Regulation of Bone Metabolism
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批准号:8776645
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项目类别:
-
资助金额:$17.83万
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财政年份:2013
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负责人:BRUCE Neil CRONSTEIN
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依托单位:
Purinergic Regulation of Bone Metabolism
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批准号:8698897
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项目类别:
-
资助金额:$13.03万
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财政年份:2013
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负责人:BRUCE Neil CRONSTEIN
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依托单位:
The Pharmacology of Dermal Fibrosis
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批准号:8698898
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项目类别:
-
资助金额:$31.65万
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财政年份:2013
-
负责人:BRUCE Neil CRONSTEIN
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依托单位:
CTSA INFRASTRUCTURE FOR CLINICAL TRIALS
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批准号:8364995
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项目类别:
-
资助金额:$42.54万
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财政年份:2011
-
负责人:BRUCE Neil CRONSTEIN
-
依托单位:
海外基金