PHARMACOLOGY OF ANTIRHEUMATIC AGENTS
PHARMACOLOGY OF ANTIRHEUMATIC AGENTS
批准号:
6115762
负责人:
BRUCE Neil CRONSTEIN
金额:
$2.1万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30
关键词:
adenosine antiinflammatory agents biological signal transduction clinical research clinical trials drug screening /evaluation enzyme linked immunosorbent assay human subject human therapy evaluation methotrexate northern blottings nucleic acid chemical synthesis polymerase chain reaction rheumatoid arthritis skeletal disorder chemotherapy skeletal pharmacology sulfanilamides
中文摘要
这项研究表明,在体内模型和类风湿性关节炎患者中,抗风湿药物,特别是甲氨蝶呤和柳氮磺胺吡啶的作用是由于它们增加细胞外腺苷的能力。 研究人员得出结论,腺苷的信号转导通过一种新的途径进行。 该实验室用于ELISA、寡核苷酸合成、PCR和重组DNA技术。
英文摘要
This study demonstrates that in in vivo models and patients with rheumatoid arthritis the effects of antiinflammatory drugs, specifically methotrexate and sulfasalzine, are due to their capacity to increase extracellular adenosine. The investigators have concluded that signal transduction of adenosine proceeds by a novel pathway. The lab was used for ELISA, oligonucleotide synthesis, PCR and recombinant DNA techniques.
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会议论文
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依托单位:
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依托单位:
海外基金