VITAMIN E AND NEUROLOGIC STATUS IN LIVER DISEASE

申请者进行的初步研究表明， 40%以上的非酒精性慢性淤胆性肝病患者 这种疾病表现为临床上明显的维生素E缺乏。 此外，还发现缺乏的严重程度是不同的。 神经功能障碍与精神运动的量化测量 赤字。这项研究将进一步评估在何种程度上 维生素E缺乏症发生在多种肝病中，其 与肝损伤严重程度的关系。此外， 拟议的调查还旨在评估在何种程度上 这种维生素缺乏症经过一个疗程后可以得到改善 维生素E补充剂。伴随着维生素E治疗， 神经功能和精神运动能力的恢复将是 监测和测量。 从这次调查中获得的发现将有助于澄清 肝性脑病的多因素病因及改进 慢性肝病患者的医疗管理。

Preliminary research conducted by the applicants indicates that over 40% of nonalcoholic patients with chronic cholestatic liver disease demonstrate a clinically significant vitamin E deficiency. The severity of deficiency has additionally been found to covary with neurologic impairment and quantitative measures of psychomotor deficit. This study will further evaluate the extent to which vitamin E deficiency occurs in a variety of liver diseases and its relationship to the severity of liver injury. Furthermore, the proposed investigation also aims to evaluate the extent to which this vitamin deficiency can be ameliorated following a course of vitamin E supplementation. Concomitant to vitamin E treatment, recovery of neurologic function and psychomotor capacity will be monitored and measured. The findings obtained from this investigation will help clarify the multifactorial etiology of hepatic encephalopathy and improve the medical management of patients with chronic liver disease.