PROSPECTIVE STUDY OF ESOTROPIS DEVELOPMENT

能否改善婴幼儿内斜视的双眼视觉预后 超越了单一固定或更糟糕的结果，通常由当前 检测和治疗方法？偏差的表现形式可以是 从一开始就被阻止了？目前(修订后的)提案将调查 存在“前驱”感觉和/或动眼神经状态的假说 在婴儿内斜视发作之前，这可能为 对这些问题的肯定回答。 拟议的研究在设计上将是纵向的，包括初步的 双目视觉、运动和屈光测量至少8254到24 正常或高危内斜视的周龄婴儿，然后进行随访 一年和两年后，以确定内斜视是否已经发展。我们的 假设是其中一个或组合中的一个会有差异 婴幼儿内斜视发生的早期干预措施 而那些不这样做的人。 双目视觉测试包括动态测量周围融合 随机点“模糊图”或“不等像像图”和动态立体视觉 随机点立体图。眼球运动将是反应的衡量标准，而眼球 还将分析跟踪记录中可能出现的动眼神经异常 它们本身就是内斜视的前驱。 所有研究参与者都将接受全面的临床检查，包括 睫状肌麻痹验光。

Can the binocular vision prognosis in infantile esotropia be improved beyond the monofixation or worse outcome typically achieved with current detection and treatment methods? Can manifestation of the deviation be prevented to begin with? The present (revised) proposal will investigate the hypothesis that there are "precursor" sensory and/or oculomotor states prior to the onset of infantile esotropia which may provide the basis for affirmative answers to these questions.l The proposed study will be longitudinal in design, comprised of initial binocular vision, motor and refractive measurements in at least 825 4 to 24 week old infants at normal or high risk for esotropia, and then follow-up one and two years later to determine if esotropia has developed. Our hypothesis is that there will be a difference in one or a combination of the early measures between the population of infants who develop esotropia and those who do not. Binocular vision tests include measurement of peripheral fusion by dynamic random dot "fusiogram" or "aniseikoniagram," and stereoacuity by dynamic random dot stereogram. Eye movements will be the response measure, and eye tracking records will also be analyzed for oculomotor anomalies that may themselves constitute esotropia precursors. All study participants will receive a full clinical examination, including cycloplegic retinoscopy.