CHEMICAL ALTERATION OF EXTRAOCULAR MUSCLE FUNCTION

我们将对A型肉毒杆菌毒素的作用进行临床试验 眼外肌治疗成人和儿童斜视 以提供有关最佳剂量、有效时间和安全性的数据 在成人和儿童身上。我们将尝试记录物理机制 通过CAT扫描、体格测量改变眼部肌肉功能 肌肉长度和张力数据，以及眼外肌的组织学。 我们会在其他情况下评估注射的效果，包括 眼睑痉挛、眼球震颤、内翻、眼睑退缩。我们将探索 其他药物对眼外肌功能的影响，尤其是 肉毒杆菌毒素-D、麻黄毒素和甲型银环蛇毒素。我们将比较 这种药物注射技术的有效性，一旦达到最佳剂量 时间表被确定，手术技术的结果是 重新调整斜视的眼睛。

We will conduct a clinical trial of the effort of botulinum-A toxin on extraocular muscle as a therapy for strabismus in adults and children in order to provide data on optimum dose, length of effectiveness, and safety in adults and children. We will attempt to document the physical mechanism by which eye muscle function is changed through CAT scan, physical measure of muscle length and tension data, and by histology of extraocular muscle. We will assess the effect of injection in other conditions including blepharospasm, nystagmus, entropion, lid retraction. We will explore the effect of other drugs on extraocular muscle function, particularly botulinum toxin-D, saxitoxin, and alpha bungarotoxin. We shall compare the effectiveness of this drug injection technique, once optimum dosage schedules are determined, with the results of surgical techniques to realign the eye in strabismus.