INFECTION ENHANCEMENT--AN EXPERIMENTAL MODEL OF SIDS

这项研究探讨了增强感染可能导致 强化的疾病。具体地说，它建议调查 非中和抗体引起的病毒感染。单核细胞的感染 登革热病毒吞噬细胞就是这种现象的原型。 最终的研究目标是确定登革热疾病的效应机制。 并评价类似的免疫病理机制和效应器 可能是触发小岛屿发展中国家的原因。因为登革热休克综合征 这与病毒感染细胞的免疫清除状态有关，这 我们的研究阶段将重点放在登革热的免疫反应上，使用 猴子模型。鉴于它们在小岛屿发展中国家中的可能作用，呼吸道合胞和 副流感病毒将在#年进行免疫增强感染研究 白细胞，在体外。

This study deals with the possibility that enhanced infection results in enhanced disease. Specifically, it proposes to investigate the mediation of viral infection by non-neutralizing antibody. The infection of mononuclear phagocytes by dengue virus is the prototype for this phenomenon. The ultimate research goal is to identify effector mechanisms in dengue disease and to evaluate analogous immunopathological mechanisms and effectors which might be responsible for triggering SIDS. Because dengue shock syndrome correlates with the state of immune elimination of virus infected cells, this phase of our research will focus on the immune response to dengue, using the monkey model. In view of their possible role in SIDS, respiratory syncytial and parainfluenza viruses will be studied for immunologically enhanced infection in leukocytes, in vitro.