Membrane Biophysics Platform

拟议的平台拨款续期旨在使我们能够利用我们作为膜生物物理学和自组装两亲材料领域世界领先集团的地位，并促进和促进英国目前支离破碎的膜生物物理界内的合作。为了实现这些目标，我们将与具有互补专业知识的小组建立合作研究网络，并通过“创意工作坊”和信息技术平台相结合，鼓励外部小组之间的相互联系。这些网络将侧重于解决生命科学接口的关键挑战，需要多学科方法。我们将支持有针对性的短期人员交流，以实现知识转让、概念验证实验和研究培训。在这一框架内，我们将邀请主要合作者作为学术访问者，并在我们系内举办系列研讨会。我们也希望继续促进更广泛的研究社区利用我们的专门设施。除了通过研究新型两亲性和复杂脂质混合物的相行为来实现我们最初目标的成功，以及开发毫秒和微秒级的溶致转变的压力跳跃同步辐射研究，我们还计划在更新的平台资助范围内开发以下研究领域，我们已确定这是生命/物理科学界面上及时而重要的挑战：i)了解膜不对称；ii)脂膜形态的蛋白质控制；iv)脂类生物合成病理途径的监管。iv)生物医学成像应用的脂类食道工程规则。

The proposed Platform grant renewal is aimed at giving us the ability to capitalise upon our position as a world leading group in membrane biophysics and self-assembled amphiphilic materials, and to promote and facilitate collaborations within the currently fragmented membrane biophysics community in the UK. To achieve these aims we will form collaborative research networks with groups having complementary expertise, and encourage interconnections between external groups via a combination of 'Ideas Workshops' and IT platforms. These networks will focus upon tackling key challenges at the Life Sciences Interface requiring multi-disciplinary approaches. We will support targeted short-term personnel exchange with a view to effecting knowledge transfer, proof-of-concept experiments and research training. Within this framework we will invite key collaborators as academic visitors and to present seminar series within our Department. We also wish to continue to facilitate exploitation of our specialised facilities by the wider research community.In addition to building upon the successes of our original objectives by studying the phase behaviour of novel amphiphiles and complex lipid mixtures, and the development of millisecond and microsceond pressure-jump synchrotron X-ray studies of lyotropic transitions, we also plan to develop the following areas of research within the renewed Platform grant, which we have identified as timely and important challenges at the Life/Physical Sciences interface:i) Understanding Membrane Asymmetry;ii) Protein Control of Lipid Membrane Morphology;iv) Regulation of Lipid Biosynthetic Pathways.iv) Lipid Mesophase Engineering Rules for Biomedical Imaging Applications.