Alkenes as Nucleophiles in Catalytic Asymmetric C-C Bond Formation

该计划旨在开发使用简单，易得的起始材料来构建更复杂的有机化学品的方法。我们的目标是使化学品具有“单手”（例如，左手）的特性，其中化学中的正常过程是产生50：50左右手分子的混合物。产生单手分子的方法已经存在，但通常是不切实际的，因为它们依赖于使用含有金属（高度反应性且对温度、空气和水敏感）的起始材料。能够使用容易获得的烯烃而不是含金属的化学品将简化化学和工业中许多非常有用的过程。这将使某些有价值的反应能够更快更有效地进行，同时最大限度地减少浪费，并以非常“绿色绿色”的方式改进工艺。

This program aims to develop methods to use simple, readily available starting materials to build up more complex organic chemicals. The chemicals we are aiming to make have the property of being 'one handed' (for example, left handed), where the normal course of events in chemistry is to produce a 50:50 mixture of right and left handed molecules. Methods to produce one handed molecules already exist but are often impractical because they rely on using starting materials that contain metals (highly reactive and sensitive to temperature, air and water). Being able to use alkenes, which are readily available, rather than metal containing chemicals would simplify a number of very useful processes in chemistry and industry. This will allow certain valuable reactions to be done much more quickly and efficiently while minimizing waste and improve the process in a very 'green' way.