NERVOUS CONTROL OF BLOOD PRESSURE

心血管的各种反射对血压的控制 该系统已在低等动物中进行了广泛的研究。结果是 已被推广到人类。有充分的证据表明，许多 已经在低等动物身上研究过的反射在 灵长类动物，因此可能不适用于人类。这部作品有 在人类身上所做的不允许分离受体系统和 因此，需要做出一些可能不正确的假设。 这项研究提案的目的是研究 颈动脉、主动脉和心肺受体在控制高血压病中的作用 灵长类动物的心血管系统。由于这项研究将涉及 有意识的灵长类动物的结果不会被 麻醉剂。它还将解决以下问题 非低血压出血和下体负压的治疗技术 正压作为选择性作用于心肺受体。在……里面 为了更彻底地解决有关卸货的问题 将进行心肺受体、主动脉和颈动脉神经记录 在麻醉猴子的非低血压出血期间。后 在有意识的灵长类动物中，反射已经被研究过， 我们将研究各种反应。一段时间以来，人们一直认为 动脉压力反射机制的变化可能导致 神经介导性高血压。这项研究将有助于回答这一问题 询问并帮助我们了解这些受体的可能参与 在病理条件下。

The control of blood pressure by the various reflexes of the cardiovascular system has been extensively investigated in lower animals. The results have been generalized to man. There is good evidence that many of the reflexes that have been studied in lower animals are not the same in the primate and therefore probably not applicable to man. The work which has been done in man does not permit the isolation of the receptor systems and therefore requires some assumptions to be made which may not be correct. The objective of this research proposal is to examine the role of the carotid, aortic and the cardiopulmonary receptors in the control of the cardiovascular system in the primate. Since the study will involve the conscious primate the results will not be clouded by the effects of anesthetics. It will also address the question of the specificity of the techniques of nonhypotensive hemorrhage and lower body negative and positive pressure as selectively effecting cardiopulmonary receptors. In order to more thoroughly address the question concerning the unloading of cardiopulmonary receptors, aortic and carotid nerve recordings will be done in the anesthetized monkey during nonhypotensive hemorrhages. After the reflexes have been examined in the conscious primate the interaction of the various reflexes will be studied. For sometime, it has been postulated that alternations in the arterial baroreflex mechanisms could result in a neurally mediated hypertension. This study will help to answer that question and help us understand the possible involvement of these receptors in pathologic conditions.