PRESSURE MONITORING SYSTEM FOR BLOOD PRESSURE CONTROL

拟议的研究是朝着我们的目标迈出的第二步 创建一种完全植入的自动给药系统 控制血压。第一步已经完成， 证明动脉脉搏波速度(PWV)跟踪舒张期 忠实地施加压力，从而消除了对植入物的需要 压力传感器。本文提出的研究旨在 证明PWV能可靠地指示慢性阻塞性肺疾病患者的血压 正常和高血压动物。 即将进行的研究将使用植入了 通过测量阻抗下降来检测脉冲的电极 在一对动脉周围电极之间。四对电极将 植入以检查不同部位脉搏的适宜性 感官。三个最好的动脉部位将被选为慢性 脉搏波传导速度与血压关系的研究我们有 已经开发了一种算法来测量逐个节拍的时间 两个动脉脉搏和脉搏的差值，这一次是PWV。 血压和PWV在正常血压和高血压患者中是相关的 动物，用运动来增加血压。此外， 动物将被注射镇静剂，并将使用药物进行关联 并降低血压。最后，在那些即将被 为电极成熟度研究做出牺牲，将建立关联 在更大范围的压力下使用毒品。在所有研究中，我们将证明 PWV(实际上是脉搏传导时间的倒数)跟踪舒张压 压力，因此可以作为一个足够的信号来控制和 植入式自动血压控制器。

The proposed research constitutes the second step toward our goal of creating a completely implanted drug-delivery system for the automatic control of blood pressure. The first step has been completed and demonstrated that arterial pulse-wave velocity (PWV) tracks diastolic pressure faithfully, thereby eliminating the need for an implantable pressure transducer. The research proposed herein is designed to demonstrate that PWV can reliably indicate blood pressure in the chronic normo- and hypertensive animal. The studies to be conducted will employ large dogs with implanted electrodes to detect the pulse by measurement of the impedance decrease between a pair of periarterial electrodes. Four pairs of electrodes will be implanted to examine the appropriateness of different sites for pulse sensing. The three best arterial sites will be selected for the chronic studies of the relationship between PWV and blood pressure. We have already developed an algorithm that measures the beat-by-beat time difference between two arterial pulses and scales this time to PWV. Blood pressure and PWV will be correlated in normotensive and hypertensive animals, with exercise to increase blood pressure. In addition, the animals will be sedated and correlations will be made using drugs to raise and lower blood pressure. Finally, in those animals that are to be sacrificed for the electrode-maturation studies, correlations will be made over a wider range of pressure using drugs. In all studies, we will show that PWV (actually the reciprocal of pulse transit time) tracks diastolic pressure, and therefore can serve as an adequate signal for controlling and automatic implanted blood-pressure controller.