PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

这是一个三年延续的纵向计划的提案 精神分裂症，抑郁症或正常父母的孩子的项目， 自1971年以来一直在进行。 研究的主要目标是 确定发展中国家的债务的早期指标， 精神分裂症或精神分裂症谱系障碍或情感障碍。 两个独立的样本，每个样本由处于危险中的儿童组组成。 这些疾病和一个低风险的精神疾病群体， 一直跟踪到受试者成年， 研究人员跟踪受试者在一段时间内的发展， 多年来，并涉及心理生物学（即，关注与信息 处理、神经运动功能和心理生理学数据）， 从儿童期的行为变量到 成年 样本A受试者最近接受了检查（第四次 时间）在成年早期。 计划对样本B进行第四轮检查 受试者在年轻的成年，可比的样本最近的评估 A. 该核心项目的进一步目标是完成对下列问题的诊断评级： 在样本B的第三次检查中进行的精神病学访谈， 从三个独立的小组获得最终诊断评估 将审查受试者终生数据的法官， 父母的诊断，并完成对收集的数据的分析， 整个研究过程，包括纵向分析和 交叉样本比较 还提出了三个子项目;每个子项目将扩展数据 对样本A和样本B中主要受试者的家庭进行收集。 在子项目l中，将对患有人格障碍的人进行访谈， 受试者及其非精神病父母（患者的配偶或 正常比较对象），以澄清频谱的性质 紊乱 在分项目2中，将进行家庭史访谈 尽可能多的家庭成员，以完成所需的信息， 基因分析 在子项目3中，主要受试者的兄弟姐妹将 考虑到与主研究组相同的临床评估组合， 在第四轮考试时，考生。

This is a proposal for a three-year renewal of a longitudinal program project on children of schizophrenic, depressed, or normal parents that has been ongoing since 1971. Major goals of the study have been concerned with the identification of early indicators of a liability to the development of schizophrenia or schizophrenia spectrum disorders or affective disorders. Two independent samples, each consisting of groups of children at risk for these disorders and a group at low risk for mental illness, are being followed until the subjects reach young adulthood to enable the investigators to trace the development of the subjects over a period of years and to relate psychobiological (i.e., attention and information processing, neuromotor functioning, and psychophysiological data) and behavioral variables studied in childhood to psychopathology emerging in adulthood. Sample A subjects have recently been examined (for the fourth time) in early adulthood. It is planned to conduct a fourth round of examinations on Sample B subjects in young adulthood, comparable to the recent assessment of Sample A. Further aims of the core project are to complete diagnostic ratings of psychiatric interviews conducted in the third examination of Sample B, to obtain final diagnostic assessments from a panel of three independent judges who will review lifetime data on the subjects blind with respect to parents' diagnoses, and to complete analyses of the data collected over the course of the entire study, including longitudinal analyses and cross-sample comparisons. Three subprojects are also proposed; each subproject will extend the data collection to the families of the main subjects in Sample A and Sample B. In Subproject l, personality disorder interviews will be conducted with the subjects and their nonpsychotic parents (spouses of patients or parents of the normal comparison subjects) to clarify the nature of spectrum disorders. In Subproject 2, family history interviews will be conducted with as many family members as possible to complete information needed for genetic analyses. In Subproject 3, siblings of the main subjects will be given the same clinical assessment battery as is administered to the main subjects at the time of their fourth round of examinations.