SOCIAL STRESS SOCIAL SELECTION AND PSYCHIATRIC DISORDERS

描述：(改编自申请者摘要)：长期目标 这项研究是为了增加对逆境在经济中的作用的理解 主要类型的精神障碍的原因是相反的 与社会经济地位(SES)有关的疾病--精神分裂症、严重抑郁症、 反社会人格、滥用药物和非特定痛苦或 “士气低落。”具体地说，该项目调查社会， 心理和家族史因素，这些因素可能在 这些精神病态的病因学和测试社会压力/社会 SES差异带来的选择问题。 以色列被选为研究背景主要有三个原因：1) 战略需要一个城市社会，在这个社会中，一个或多个 最初处于不利地位的种族团体正在发生；2)以色列人 在不寻常和正常的压力环境中 国家的战争史；以及3)在以色列存在一个保存完好的 人口登记便于对出生队列进行抽样。 自1982年以来，这项研究一直集中在全国范围内的一群年轻人身上 成年的以色列出生的犹太人，来自相对不利的北非和 相对较有优势的欧洲背景。筛查和诊断 采访是以4914个全概率样本进行的 人。361名被诊断为关键类型的人的亚样本 精神障碍和198名被诊断为无精神障碍的人 是从更大的样本中挑选出来的，并进行了密集的跟踪 关于可能的风险因素的采访。筛选面试一直在进行 与大多数精神病病例中至少一个兄弟姐妹一起进行 控制。 4914名社员流行病学抽样调查资料的主要分析 已经完成并上报了。本次大赛的目的是 续展申请均需完成处理和统计 对361例病例和198例对照的详细数据进行了分析，包括 他们兄弟姐妹的数据。与完成的分析放在一起 在流行病学数据中，对病例/控制数据的拟议分析 将提供压力选择问题的系统测试和一个主要的 有助于理解逆境的作用。

DESCRIPTION: (Adapted from Applicant's Abstract): The long term goal of this research is to increase an understanding of the role of adversity in the causation of the main types of psychiatric disorders that are inversely related to socio-economic status (SES) -- schizophrenia, major depression, anti-social personality, substance abuse, and nonspecific distress or "demoralization." Specifically, the project investigates the social, psychological, and family history factors that may be important in the etiology of these psychopathologies and tests the social stress/social selection issue posed by SES differences. Israel was chosen as the research setting for three main reasons: 1) the strategy required an urban society in which the assimilation of one or more initially disadvantaged ethnic groups is taking place; 2) Israelis have been exposed to unusual as well as usual stressful circumstances during the country's history of war; and 3) the existence in Israel of a well-kept population register facilitated the sampling of a birth cohort. Since 1982, this research has focused on a nationwide cohort of young adult, Israeli-born Jews from relatively disadvantaged North African and relatively advantaged European backgrounds. Screening and diagnostic interviews have been conducted with a full probability sample of 4914 persons. Subsamples of 361 persons diagnosed as having the key types of psychiatric disorders and 198 persons diagnosed as having no disorders have been selected from the larger sample and followed-up with intensive interviews about possible risk factors. Screening interviews have been conducted with at least one sibling of most of these psychiatric cases and controls. The main analyses of the data from the 4914 member epidemiological sample have been completed and reported. The purposes of this competing continuation application are to complete processing and statistical analyses of the detailed data on the 361 cases and 198 controls, including the data from their siblings. Taken together with the completed analyses of the epidemiological data, the proposed analyses of the case/control data would provide a systematic test of the stress-selection issue and a major contribution to an understanding of the role of adversity.