CEREBRAL ISCHEMIA VIABILITY AND OXIDATIVE METABOLISM

中详细介绍的工作是利用 细胞内氧化代谢活性的指标来评估变化 发生在脑缺氧/缺血期间，并确定最多的因素 在循环期及之后对整体组织活力至关重要 妥协。非侵入性荧光检测技术在脑出血中的应用 线粒体内NAD的还原/氧化比率及其技术 反射分光光度同时测定细胞色素的氧化还原变化 随着血红蛋白氧合和局部血容量的变化，将被利用。 通过将新陈代谢参数和功能参数联系起来，我们将了解到 功能活动的易损性与缺血期有关 侮辱。我们将继续努力定义能源之间的关系 新陈代谢和中枢神经系统的功能来增加我们的 了解大脑如何以及为什么利用氧气、代谢底物和 氧化能量，并确定如何威胁生存能力的损失 氧气和循环灌流。

The efforts detailed within are steps in the overall goal of utilizing intracellular indicators of oxidative metabolic activity to assess the changes that occur during cerebral anoxia/ischemia and to determine the factors most critical to overall tissue viability during and following periods of circulatory compromise. Non-invasive techniques of fluorometrically monitoring changes in the reduction/oxidation ration of intramitochondrial NAD and the technique of reflection spectrophotometry to measure redox changes of cytochromes together with changes in hemoglobin oxygenation and local blood volume will be utilized. By relating parameters of metabolism and function, we will discern how vulnerability of functional activity is associated with periods of ischemic insult. We will continue efforts to define the relationships between energy metabolism and the functioning of the central nervous system to increase our understanding of how and why the brain uses oxygen, metabolic substrates and oxidative energy and to determine how viability is threatened by the loss of oxygen and circulatory perfusion.