NEUROLOGY OF MEMORY

本课题的一个主要目的是建立一种双颞叶的动物模型， 人类健忘症 建立了一种实验性的动物模型， 人类临床疾病实体的研究一直是 神经科学研究的目标。 我们提出了一个学习计划， 猴子的双颞脑区域参与了 人类健忘症和正常的人类记忆过程。 这个研究项目 应该有助于确定哪些特定的大脑结构参与了人类 失忆症，并澄清他们是如何参与的。 具体来说，这项工作是 目的是：1）进一步阐明分离或分离对记忆的影响， 猴子的海马体和杏仁核的双侧损伤， 当用四个类似于人类敏感的任务测试记忆时， 健忘症; 2）确定分心对两个人的表现的影响 延迟型任务在正常和操作的猴子; 3）确定是否 新制定的区别，这种学习，这是不遗余力 在人类健忘症和哪些不是，可以证明在猴子与 颞叶病变 性能将根据模式进行比较 辨别学习和物体辨别的延迟保持; 4） 确定双颞叶病变的影响是否延伸到两个识别 记忆力（记住两个物体中哪一个同样熟悉的能力） 和联想记忆（记住两个中哪一个相等的能力） 熟悉的物体与奖励有关）。 等效试验 将给予所有组识别和联想记忆。 第五章） 确定双颞叶病变的行为影响是否超出了 通过在听觉模式下进行类比测试的视觉模式; 6） 确定发病前和发病后之间是否存在间断 对正常猴进行双颞叶损伤手术， 他们以前学过这些任务，并重新测试它们。

A major goal of this project is to establish an animal model of bitemporal human amnesia. The development of an experimental animal model for the study of a clinical disease entity in humans has always been one of the goals of neuroscience research. We are proposing a program of study in monkeys involving the bitemporal brain regions that have been implicated in human amnesia, and in normal human memory processes. This research program should help identify which specific brain structures are involved in human amnesia and clarify how they are involved. Specifically, the work is designed to 1) clarify further the effects on memory of separate or combined bilateral damage to the hippocampus and the amygdala in monkeys, when memory is tested with four tasks similar to those sensitive to human amnesia; 2) determine the effects of distraction on the performance of two delay-type tasks in normal and operated monkeys; 3) determine whether a newly formulated distinction, between that kind of learning which is spared in human amnesia and that which is not, can be demonstrated in monkeys with temporal lobe lesions. Performance will be compared on pattern discrimination learning and delayed retention of object discriminations; 4) determine if the effects of bitemporal lesions extend to both recognition memory (the ability to remember which of two objects is equally familiar) and association memory (the ability to remember which of two equally familiar objects was associated with reward). Equivalent tests of recognition and association memory will be given to all groups. 5) Determine if the behavioral effects of bitemporal lesions extend beyond the visual modality by administering analagous tests in the auditory mode; 6) determine if there is a discontinuity between premorbid and postmorbid memory in monkeys with bitemporal damage by operating on the normal group who have previously learned the tasks and retesting them.