THE NEUROLOGY OF MEMORY

本项目的一个主要目标是建立双时相动物模型。 人类健忘症。大鼠局灶性脑出血动物模型的建立 对人类临床疾病实体的研究一直是 神经科学研究的目标。我们正在提议一项研究计划。 猴子涉及双颞叶大脑区域，已被牵连到 人类健忘症，在正常的人类记忆过程中。这项研究计划 应该有助于确定哪些特定的大脑结构参与了人类 并澄清他们是如何参与其中的。具体来说，这项工作是 旨在1)进一步澄清分开或分开的对记忆的影响 猴子双侧海马体和杏仁体的联合损伤， 当用四个与人类敏感的任务相似的任务测试记忆时 健忘症；2)确定分心对两个人的表现的影响 在正常和操作的猴子中的延迟型任务；3)确定 新制定的区别，在这种学习是幸免的 在人类健忘症和非健忘症中，可以在猴子身上证明 颞叶损伤。性能将在模式上进行比较 辨别学习与物体辨别的延迟保持；4) 确定双颞叶病变的影响是否延伸到两种识别 记忆力(记住两个物体中哪一个同样熟悉的能力) 和联想记忆(记住两个中哪一个相等的能力 熟悉的物体与奖励有关)。等价性检验 所有小组都将获得认可和联想记忆。5) 确定双颞叶病变的行为影响是否超出 在听觉模式下进行类比测试的视觉通道；6) 确定病前和病后之间是否有间断 正常组双暂时性损伤猕猴的记忆功能 他们之前已经学习了这些任务，并重新进行了测试。

A major goal of this project is to establish an animal model of bitemporal human amnesia. The development of an experimental animal model for the study of a clinical disease entity in humans has always been one of the goals of neuroscience research. We are proposing a program of study in monkeys involving the bitemporal brain regions that have been implicated in human amnesia, and in normal human memory processes. This research program should help identify which specific brain structures are involved in human amnesia and clarify how they are involved. Specifically, the work is designed to 1) clarify further the effects on memory of separate or combined bilateral damage to the hippocampus and the amygdala in monkeys, when memory is tested with four tasks similar to those sensitive to human amnesia; 2) determine the effects of distraction on the performance of two delay-type tasks in normal and operated monkeys; 3) determine whether a newly formulated distinction, between that kind of learning which is spared in human amnesia and that which is not, can be demonstrated in monkeys with temporal lobe lesions. Performance will be compared on pattern discrimination learning and delayed retention of object discriminations; 4) determine if the effects of bitemporal lesions extend to both recognition memory (the ability to remember which of two objects is equally familiar) and association memory (the ability to remember which of two equally familiar objects was associated with reward). Equivalent tests of recognition and association memory will be given to all groups. 5) Determine if the behavioral effects of bitemporal lesions extend beyond the visual modality by administering analagous tests in the auditory mode; 6) determine if there is a discontinuity between premorbid and postmorbid memory in monkeys with bitemporal damage by operating on the normal group who have previously learned the tasks and retesting them.