Hemilabile and Switchable Metal-Organic Frameworks

这项拨款提案来自一组研究人员，他们的专业知识涵盖了多孔材料的合成、表征和吸附研究。该项目是发展和推广金属有机框架（MOF）化学中的两个新概念，该团队最近在《自然化学》上发表了这两个新概念。总体目标是为mof的性质（包括材料的稳定性）提供一个阶段性的变化，以实现目前不可能实现的新型化学。要做到这一点，需要对初步概念进行概括，以最大限度地发挥其在学术和长期商业领域的影响（见影响声明）。这项工作新颖的另一个特点是应用了先进的表征技术，包括x射线对分布函数分析和原位x射线衍射以及结合吸附/中子衍射来探测所制备材料的结构和性能。金属有机框架（mof）是近十年来最令人兴奋和发展最快的材料之一。这些固体化学性质的多样性导致了超高孔隙度、极高的柔韧性、合成后改性的潜力以及许多其他有趣和有用的特性。由于这种广泛的化学和功能，这些固体的潜在应用范围从气体储存，分离和输送，催化和传感一直到生物和医学。在英国，我们在这些领域有很强的实力，在高多孔材料和储氢，手性和仿生mof，合成后改性，计算方面，晶体生长和几个优秀的合成/材料组。然而，在这个快速发展的领域，国际竞争是激烈的。在epsrc资助的名为“定向组装具有目标特性的扩展结构”的网络中，开发合成本身作为获得有用属性的途径的重要性已被认为是一个“重大挑战”。这个地区的国家重要性隐含在它被指定为“大挑战”中。随着该领域的发展，人们越来越关注mof的基础和应用方面的发展。

This grant proposal comes from a team of researchers with expertise spanning synthesis, characterisation and adsorption studies of porous materials. The project is to develop and generalise two new concepts in metal-organic framework (MOF) chemistry that the team have recently published in Nature Chemistry. The overall goal is to provide a step change in the properties of MOFs (including stability of the materials) to enable new types of chemistry that are not currently possible. To do this requires that the preliminary concepts are generalised to maximise their impact in both the academic and, in the long term, commercial worlds (see impact statement). An added feature of the novelty of this work is the application of advanced characterisation techniques, including X-ray pair distribution function analysis and in situ X-ray diffraction and combined adsorption/neutron diffraction to probe the structure and properties of the materials prepared.Metal-organic frameworks (MOFs) are some of the most exciting and fast-developing materials that have been prepared in the last decade or so. The great versatility of the chemistry of these solids leads to ultra-high porosity, extreme flexibility, post synthetic modification potential and many other interesting and conceivably useful attributes. Because of this wide ranging chemistry and function, potential applications of these solids range from gas storage, separation and delivery, catalysis, and sensing all the way to biology and medicine. In the UK we have great strength in variety of these areas, in highly porous materials and hydrogen storage, chiral and bio-inspired MOFs, post-synthetic modification, computational aspects, crystal growth and several excellent synthetic/materials groups. However, the international competition is great in this rapidly growing area. The importance of developing the synthesis itself as a route to useful attributes has been recognised as a 'Grand Challenge' in the EPSRC-funded network entitled Directed Assembly of Extended Structures with Targeted Properties. The national importance of this area is implicit in its designation as a Grand Challenge. As the field moves on there is a great focus on developing both the fundamental and applied aspects of MOFs.