METHANE PRODUCTION ON LOW AND HIGH FIBER DIETS

需要筛查方法来预测发生结肠癌的风险。 癌症。那些被确定为结肠癌高危人群 会更有动力做出适当的饮食改变。近期 研究表明，结肠癌患者更有可能排泄 呼气甲烷高于健康对照组。《公约》的总体目标 拟议的研究是在一大群人中观察呼气甲烷的排泄情况 低纤维和高纤维饮食的受试者。将有两组受试者 研究表明，那些低纤维饮食的人和那些食用含有 国家癌症协会推荐的膳食纤维摄入量为30至40克 研究所。膳食纤维、蛋白质、大便重量、转运时间、频率 所有受试者的大便和大便酸碱度都将被测量。多个 将进行回归分析，以确定呼吸的最佳预测因子 甲烷排泄物。 在后续研究中，受试者在最初食用低纤维饮食 研究将给予25克的膳食纤维作为小麦麸皮和相同的 参数将按照第1部分中的方式进行测量。建议的研究应 确定哪些参数是呼气甲烷的最佳预测因子 制作。此外，呼气甲烷将在一个大的 低纤维饮食和高纤维饮食的受试者数量。我们应该有好的数据 呼气甲烷是否会随着饮食或时间的推移而变化。

Screening methods are needed to predict the risk of developing colon cancer. Those identified to be at high risk for developing colon cancer would be more motivated to make appropriate dietary changes. Recent research suggests that colon cancer patients are more likely to excrete breath methane than healthy control subjects. The overall objective of the proposed research is to look at breath methane excretion in a large group of subjects on low and high fiber diets. Two groups of subjects will be studied, those on low fiber diets and those consuming diets containing the 30 to 40 grams of dietary fiber recommended by the National Cancer Institute. Dietary fiber, protein, stool weight, transit time, frequency of defecation, and stool pH will be measured for all subjects. A multiple regressioin analysis will be run to determine the best predictors of breath methane excretion. In a follow-up study, the subjects consuming low fiber diets in the initial study will be given 25 grams of dietary fiber as wheat bran and the same parameters will be measured as in part 1. The proposed studies should determine what parameters are the best predictors of breath methane production. Also, breath methane will be measured repeatedly in a large number of subjects on low and higher fiber diets. We should have good data whether breath methane changes with diet or over time.