CONFERENCE ON SELF REACTIVITY AND ITS REGULATION

近一个世纪以来，免疫学家一直面临着令人困惑的问题 免疫系统如何与自我和谐共处的问题，以及 在这段时间的大部分时间里，结论是它避免了 全部与自身分子发生反应。最近，结构分析 T细胞受体的分子，由主要的 组织相容性复合体和基因的详细信息 重排，结合使用Flow的细胞/遗传分析 细胞学和转基因动物提供了工具 对这一中心问题的革命性重新审视。已经有了一个 在过去2到3年内关于该主题的信息爆炸式增长，以及 以下问题(和发现)已经得到了激烈的实验 审查：a)个体发育过程中的自我学习(积极选择 自身MHC分子与自身免疫球蛋白和T细胞的识别 受体)；b)自我耐受机制(通过克隆进行负选择 胸腺中的缺失；克隆性无能的诱导和繁殖 外周T和B细胞；c)调节危险的自身反应性 抗TCR或MHC决定簇的单抗.肽抑制 自身分子与MHC的结合；TCR-肽对调节性T细胞的诱导 细胞)；d)自相矛盾的自身反应(多特异性抗体， 独特型连接，热休克蛋白与自身免疫相关， 等)。召开这次会议的目的是帮助 促进自我-非我的分子基础的出现 歧视。这可能会对如此关键的 自身免疫性疾病、传染病(自我模仿)等问题 寄生虫)，以及免疫反应性的调节。

For nearly a century, immunologists have confronted the perplexing problem of how the immune system coexists harmoniously with the self, and for the great majority of this period, the conclusion was that it avoided all reactivity with self-molecules. Most recently, structural analysis of the T cell receptor, molecules produced by the major histocompatibility complex, and detailed information on gene rearrangement, coupled with cellular/genetic analysis using flow cytometry and transgenic animals, have provided the tools for a revolutionary reexamination of this central issue. There has been an explosion of information within the last 2 to 3 years on this topic, and the following issues (and findings) have received intense experimental scrutiny: a) The learning of self during ontogeny (positive selection governed by self-MHC molecules and the recognition of self-Ig and T-cell receptors); b) Mechanisms of self tolerance (negative selection by clonal deletion in the thymus; induction and propagation of clonal anergy in peripheral T and B cells; c) Modulating dangerous autoreactivity (monoclonal antibodies to TcR or MHC determinants; peptide inhibition of binding of self-molecules to MHC; TcR-peptide induction of regulatory T cells); d) Paradoxical self-reactivity (multispecific antibodies, idiotypic connectivity, heat shock protein association with autoimmunity, etc.). This meeting will be convened with the goal of helping to facilitate the emergence of a molecular basis for self-non-self discrimination. This could have direct repercussions on such crucial problems as autoimmune disease, infectious disease (mimicry of self by parasites), and the regulation of immune reactivity.