1989 GORDON RESEARCH CONFERENCE ON PROTEINS

为戈登研究会议的部分支持寻求资金 (GRC)1989年关于蛋白质的预算，将用于支助旅行和住宿， 邀请演讲者和年轻科学家的董事会。与其他GRC一样， 蛋白质会议是一个小型的，独特的论坛，新的结果可以 在有助于交换意见的非正式场合进行讨论， 制定合作研究计划。蛋白质GRC已被 在奇数年举行的一年两次的会议。1988年的会议是 一项实验，以确定改变年度格式是否 有正当理由关于这一点的最后决定将在1989年的会议上作出， 与会者。 近年来，有三个因素彻底改变了蛋白质的研究。 克隆技术的出现加上过度- 表达载体使生物化学、细胞生物学和 许多蛋白质结构研究迄今只能在几分钟内进行 金额。定向诱变的使用提供了询问和鉴定突变体的能力。 回答更详细和高度集中的问题比有 传统上是可寻址的。X射线晶体学的改进 方法意味着更多的结构正在被确定。一起 这些技术引起了蛋白质研究的复兴。的 该计划将强调进展特别迅速的领域， 在理解蛋白质的生物学功能和活性方面， 他们的结构。 尽管该计划仍在不断变化，但我们已经确定了 以下会议标题：-蛋白质折叠和展开的能量学，- 转运/受体：膜、通道和孔，-实验探针 蛋白质动力学，-应用工具的分子：二氢叶酸 还原酶和葡萄球菌核酸酶，-X射线结构，-进化和 结构（和匡威）-肽模型的遗传探针

Funds are sought for partial support of the Gordon Research Conference (GRC) on Proteins for 1989 and will be used to support travel and room and board for invited speakers and young scientists. Like other GRC's the Conference on Proteins is a small, unique forum where new results can be discussed in an informal setting conductive to the exchange of ideas and the creation of plans for collaborative research. The Proteins GRC has been a biannual conference given in odd-numbered years. The 1988 conference was an experiment to determine whether a change to an annual format was warranted. A final decision about this will be made at the 1989 meeting by the attendees. Three factors have revolutionized the study of proteins in recent years. The advent of cloning technology coupled with the development of over- expression vectors has made possible the biochemical, cell-biological and structural study of many proteins hitherto only available in minute amounts. The use of directed mutagenesis provides the ability to ask and answer much more detailed and highly focussed question than have traditionally been addressable. The improvement in x-ray crystallographic methods means that many more structures are being determined. Together these techniques have evoked a renaissance in the study of proteins. The program will emphasize areas where particularly rapid progress is being made in understanding the biological function and activity of proteins in terms of their structures. Although the program is still very much in flux, we have identified the following session titles: -Energetics of Protein Folding and Unfolding, - Transport/Receptors: membranes, channels and pores, -Experimental Probes of Protein Dynamics, -Applications of tools to molecules: dihydrofolate reductase and staphylococcal nuclease, -X-ray structures, -Evolutionary and genetic probes of Structure (and the Converse), -Peptide Models