FASEB SUMMER CONFERENCE-MOLECULAR ASPECTS OF METASTASIS

这是一项为支持第二次FASE B夏季研究的基金提出的建议 肿瘤转移的分子方面会议(利奥·T·福尔希特大学 明尼苏达州，主席和乔治·R·马丁，国家老龄研究所，联合 主席)。第一次会议有大约100名科学家参加， 与会者在他们的评价问卷中给予了非常高的评价。 转移是癌症自然发展史中的一个关键事件 对于大多数死亡来说。许多调查人员已经做了很多工作来确定这些步骤 在转移瘤中，能够激活转移表型的癌基因 以及生长因子和基质分子等宿主因素的作用。 这项工作的大部分都是用黑色素瘤细胞系进行的，并已经 已使用静脉注射注射这些细胞以获得转移活性。这 会议将通过强调以下独特方面而脱颖而出 人类的主要癌症--乳腺癌、结肠癌、肺癌和前列腺癌--一次会议 由吉姆·穆尔肖恩、国家癌症研究所和马克·李普曼组织。 与癌症进展相关的因素和抑制基因的作用 还将强调这一点。四次会议将处理转移细胞 包括分子和细胞行为。其中一次会议将 将在每个课程的节目中添加简短的演示文稿，以 确保广泛参与。药理调节的途径 将由Olden和Gottesman组织。关于以下方面的新信息 我们将讨论血管生成和卡波西肉瘤。因此，这次会议 应该与从事不同领域癌症研究的人一起 研究转移的研究人员并协助开发方法以 抑制重要人类癌症的扩散。

This is a proposal for funds to support the second FASEB Summer Research Conference on Molecular Aspects of Metastasis (Leo T. Furcht, University of Minnesota, Chair and George R. Martin, National Institute on Aging, Co- Chair). The first conference was attended by about 100 scientists and was rated very highly by the attendees in their evaluation questionnaires. Metastasis is a critical event in the natural history of cancer responsible for most deaths. Numerous investigators have done much to define the steps in metastases, oncogenes that are able to activate the metastatic phenotype and the role of host factors such as growth factors and matrix molecules. Much of this work has been carried out with lines of melanoma cells and has utilized i.v. injection of these cells to score metastatic activity. This conference will distinguish itself by emphasizing the unique aspects of the major human cancers--breast, colon, lung, and prostate--in a session organized by Jim Mulshine, National Cancer Institute, and Marc Lippmann. Factors associated with cancer progression and the role of suppressor genes will also be emphasized. Four sessions will deal with metastatic cells including molecular and cellular behavior. One of these sessions will involve short presentations will be added to each session's program to ensure broad participation. Approaches to the pharmacological modulation of metastases will be organized by Olden and Gottesman. New information on angiogenesis and Kaposi's sarcoma will be discussed. Thus, this meeting should join persons working in diverse areas of cancer research with researchers studying metastasis and assist in developing methods to suppress the spread of important human cancers.