BIOMECHANISMS OF TOOTH ERUPTION,RESORPTION & REPLACEMENT

牙齿的萌出和牙根的吸收都是现象 与头面部的生长发育有关。而正常的 这些过程的进展已经被详细描述，一些 存在异常情况，通常通过机械手段来解决。 这些异常包括喷发在时间和地点上的偏差， 乳牙过早或延迟脱落，牙齿强直。 牙根吸收在正畸治疗中尤其值得关注。 运动，以及在牙槽骨损伤后。牙科植入物正在被 用于修复成人缺失的牙齿，也可作为支抗装置 正畸学。它们由惰性物质(如钛)或生物活性物质(如钛)制成。 羟基磷灰石)材料，大多数都达到了不同程度的 骨性融合，类似于关节强直。然而，在不断增长的患者中 可能需要使用不与骨结合的植入物，而是 开发一种牙周韧带样结构，使种植成为可能 喷发。 最近的报告表明，矿化和非矿化的连接体 组织的生长和维持以及上皮-间充质的相互作用 受自分泌和旁分泌信号以及分子的调节 来自神经、免疫和内分泌系统，以及来自 节食。此外，这些组织生长和重塑在 身体上的压力。由此产生的菌株可能在刺激 细胞，维持组织的完整性，并调节过程，如 牙萌出、牙根吸收和种植体-组织整合。这个 本次会议的总体目标是促进讨论和 提供关于生物本质的证据，关于分子-细胞 牙萌出、吸收和替换的水平，以及 坚信这些知识将增强我们的临床能力。 这次会议的目的是召集一群调查人员，他们是 积极参与牙萌出、吸收等方面的研究 细胞-细胞和细胞-基质相互作用的相关领域； 神经、免疫和内分泌系统的相互作用在调节 结缔组织代谢，重点是结缔组织代谢调节机制 骨骼细胞和牙齿细胞。会议将尝试将 与牙齿相关的一般和特殊生物信息 喷发、吸收和置换，以扩大和加深我们的 了解这些发育和临床现象，并促进 我们有能力实施更好的治疗手段来预防和纠正 异常现象。观众将由大约240人组成。这个 会议记录将出版并分发给所有人 参与者，以及世界上每一所牙科学校的图书馆。

The eruption of teeth and the resorption of their roots are phenomena associated with craniofacial growth and development. While the normal progression of these processes has been described in detail, a number of abnormalities exist, which are usually addressed by mechanical means. These abnormalities include eruption deviations in time and location, premature or delayed exfoliation of deciduous teeth, and tooth ankylosis. Root resorption is of particular concern during orthodontic tooth movement, and following dentoalveolar trauma. Dental implants are being used to replace missing teeth in adults, and as anchorage units in orthodontics. They are made of inert (e.g. titanium) or bioactive (e.g. hydroxyapatite) materials, and most achieve various degrees of osseointegration, which resembles ankylosis. However, in growing patients it may be desirable to use implants that do not osseointegrate, but rather develop a periodontal ligament-like structure that would permit implants to erupt. Recent reports suggest that mineralized and non-mineralized connective tissue growth and maintenance, and epithelial-mesenchymal interactions are regulated by autocrine and paracrine signals, as well as by molecules derived from the nervous, immune, and endocrine systems, and from the diet. Moreover, these tissues grow and remodel under the influence of physical stresses. The resulting strains may be pivotal in stimulating cells, maintaining tissue integrity, and regulating processes such as tooth eruption, root resorption, and implant-tissue integration. The overall objective of this conference is to promote discussions and to provide evidence on the biological nature, on the molecular-cellular levels, of tooth eruption, resorption, and replacement, with the conviction that such knowledge will strengthen our clinical capabilities. The aim of this conference is to assemble a group of investigators who are actively involved in research on tooth eruption, resorption, and replacement, and related areas of cell-cell and cell-matrix interactions; nervous, immune, and endocrine system interactions in the regulation of connective tissue metabolism, with emphasis on regulatory mechanisms of skeletal and dental cells. The conference will attempt to integrate general and specific biologic information with that related to tooth eruption, resorption, and replacement, in order to broaden and deepen our understanding of these developmental and clinical phenomena, and foster our ability to administer better therapeutic means to prevent and rectify abnormalities. The audience will consist of about 240 individuals. The conference's proceedings will be published and distributed to all participants, and to every dental school library in the world.