CONFERANCE ON REGULATION OF TRANSCRIPTION ELONG AND TERM

1991年应该是举行一次大规模机制会议的好时机 转录延长和终止，这将把 原核生物和真核生物系统的研究人员。已经存在了 关于这个主题的原核生物研究的大量背景。不过，这个 数据目前正在进行重大的重新评估，新的模型正在 正在浮现。真核生物的研究不那么先进，但意义重大 几乎每个月都会有出人意料的结果被报道。在以下领域中 目前的兴趣如下：1)由RNA聚合酶I终止， 线粒体聚合酶，可能还有一些聚合酶II基因 一个位点特异的DNA结合蛋白的意想不到的作用，一个相对 新的机制。也有报道说，聚合酶III可能利用一种 小核RNP促进转录的终止/释放。2) 几个重要的原癌基因(myc和myb)以及某些病毒 基因(艾滋病病毒)利用停顿和终止来调节基因 表情。3)mRNA3‘加工(Polya加成)的位置有一个 对终止位点选择和mRNA稳定性有很强的影响 目前尚不清楚的机制。相反，在某些情况下， 终结符本身似乎也是 起爆地点。所有这些地区都在积极调查中，并 将会是一次激动人心的会议。

1991 should be a good time to hold a large-scale conference on mechanisms of transcription elongation and termination that would bring together researchers in both prokaryote and eukaryote systems. There already exists a large background of research in prokaryotes on this topic. However, this data is currently undergoing significant re-evaluation and new models are emerging. Research in eukaryotes is less advanced but significant and unexpected results are being reported almost monthly. Among areas of current interest are the following: 1) Termination by RNA polymerase I, mitochondrial polymerase, and possibly some polymerase II genes involves the unexpected action of a site-specific DNA binding protein, a relatively novel mechanism. Also there are reports that polymerase III may utilize a small nuclear RNP to facilitate termination/release of the transcript. 2) Several important proto-oncogenes (myc and myb), as well as certain viral genes (AIDS virus) utilize pausing and termination to regulate gene expression. 3) The site of mRNA 3' processing (polyA addition) has a strong effect on termination site selection and mRNA stability via mechanisms that are yet unknown. Conversely, there are instances where the terminator itself appears to also function as an integral component of the initiation site. All of these areas are under active investigation and will make for an exciting meeting.