BONE INGROWTH/REMODELING IN CEMENTLESS KNEE ARTHROPLASTY

骨长入多孔法固定骨科植入物 表面作为丙烯酸水泥的替代品正在研究中 在全髋关节和膝关节置换手术中。的长期目标 本项目旨在解决金属材料使用中的三个关键问题 多孔涂层在全膝关节置换术中的应用 关节置换术：(1)初始刚体与关节的关系 切向界面位移和组织生长，(2) 植入物组织学的力学相关性 界面和(3)与骨重建相关的长期方面 非骨水泥全膝关节置换术。 将使用全膝关节置换模型，其中的方法是 将改变佐剂固定以改变初始的 刚体稳定性与切向界面形态 位移。在三个实验中的第一个，物理实验 初始位移的测量结果将与 术后1个月、6个月、24个月组织学观察。在第二个 实验，界面位移的物理测量 将在植入六个月后制作，并 与界面的组织学相关联。在第三节 实验，建筑和重塑动态的变化 胫骨近端将作为自然功能进行研究。 术后1个月、6个月和24个月的骨-种植体界面。 这些实验将(1)有助于定义最大值 骨-种植体与骨相容的相对微动量 向内生长，(2)解决骨向内生长多少的问题 需要确保组件稳定性和(3)确定如何 骨-种植体界面性质的变化会影响骨 胫骨近端的重塑。

Fixation of orthopedic implants by bone ingrowth into porous surfaces is being investigated as an alternative to acrylic cement in total hip and knee arthroplasty. The long-term objectives of this project are to address three key issues in the use of metallic porous coatings for the tibial component in total knee arthroplasty: (1) the relationship between initial rigid body and tangential interface displacements and tissue ingrowth, (2) the mechanical correlates of the histology of the bone-implant interface and (3) long-term aspects of bone remodeling related to cementless total knee replacement. A total knee replacement model will be used in which the method of adjuvant fixation will be altered in order to vary the initial rigid body stability and pattern of tangential interface displacements. In the first of three experiments, physical measurements of the initial displacements will be correlated with histologic findings 1,6 and 24 months after surgery. In the second experiment, physical measurements of the interface displacements will be made after a six month period of implantation and correlated with the histology of the interface. In the third experiment, changes in the architecture and remodeling dynamics of the proximal tibia will be investigated as a function of the nature of the bone-implant interface at 1, 6 and 24 months. These experiments will (1) facilitate definition of the maximum amount of relative bone-implant micromotion compatible with bone ingrowth, (2) address the question of how much bone ingrowth is needed to ensure component stability and (3) determine how variation in the nature of the bone-implant interface affects bone remodeling in the proximal tibia.