PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

这是一份纵向续签五年的提案。 年儿童项目(纽约高危项目) 精神分裂症、抑郁症或正常父母，一直在进行 自1971年以来。SUTDY的主要目标一直与 确定对以下方面的责任的早期指示者 精神分裂症或精神分裂症谱系障碍的发展。 在本赠款期间，该项目扩大到包括 研究儿童以前未被研究的兄弟姐妹，以及更大 关注父母，这些额外的科目将继续 在更新换代的几年里要研究。 在拟议的续期期间，所有科目都将 作为成年人学习，主要目标涉及：(1)评估 经历过(或有)疾病的受试者的早期疾病 最近经历的)第一次精神障碍发作；(2) 继续研究精神分裂症谱系的概念， 使用我们的示例尝试定义具有高 精神分裂症患者亲属的敏感性和特异性 先证者；(3)继续学习注意力和信息 加工(AIP)测量和平滑追踪眼动(SPEM) 关于：他们向成年人预测的准确性 精神障碍，它们对精神分裂症和 相关障碍、状态-特质问题和家族聚集性； (4)更新对所有家庭成员的诊断评估；(5) 进行了一些与差异有关的遗传分析 风险估计、遗传力和家系分离 AIP和SPEM的临床特点和测量方法；(6)收集 用于保存精神分裂症患者家属DNA的血液样本 父母。此外，我们希望研究可能的缓冲区和 压力源。

This is a proposal for a five-year renewal of a longitudinal project (the New York High-Risk Project) on children of schizophrenic, depressed or normal parents, which has been ongoing since 1971. Major goals of the sutdy have been concerned with the identification of early inbdicators of a liability to the development of schizophrenia or schizophrenis spectrum disorders. In the current grant period, the project was extended to include previuosly-not-studied siblings of the study children, and greater focus on the parents, and these additional subjects will continue to be studied in the renewal years. In the proposed renewal period, in whioch all subjects will be studied as adults, major goals are concerned with: (1) assessing early stages of illness in subjects who experience (or have recently experienced) a first episode of psychiatric disorder; (2) continuing to examine the concept of the schizophrenia spectrum, using our samples to attempt to define criteria with high sensitivity and specificity for relatives of schizophrenic probands; (3) continuing to study attentional and information processing (AIP) measures and smooth pursuit eye movements (SPEM) with respect to: the accuracy with which they predict to adult psychiatric disorders, their specificity for schizophrenia and related disorders, state-trait questions, and familial clustering; (4) updating diagnostic assessments on all family members; (5) carrying out a number of genetic analyses relating to differential risk estimates, and heritabilities and familial segregation of clinical features and of AIP and SPEM measures; (6) collecting blood samples to preserve DNA in the families of schizophrenic parents. Additionally, we hope to study possible buffers and stressors.