TOTALLY BIOABSORBABLE COMPOSITE BONE FIXATION DEVICE

生物可吸收聚合物的制备引起了人们的极大关注 骨折内固定装置；然而，它们的机械性能， 尤其是对于长骨固定来说，弹性模数是不够的。为了 解决这个问题，并且仍然保留可生物降解性和 聚合物的生物相容性，完全生物可吸收的概念 纤维增强复合材料是最近出现的一种复合材料。然而，系统 到目前为止，报道的有机纤维中含有的可生物降解物质一般都会丢失 几天内的强劲势头，表明持续的困难 将这种纤维偶联到可降解聚合物上。 这项提议的具体目的是引入表面的概念 改善复合材料界面粘结性能的改进措施 完全可吸收复合骨中的可吸收纤维和基质 固定装置。这种表面处理还可以延缓水解物的降解 增强纤维及其基质的降解率。这样的一种 预计改进将解决目前的主要技术难题 在完全可吸收的复合接骨板中遇到。

Bioabsorbable polymers have received considerable attention for making internal fracture fixation devices; however, their mechanical properties, particularly modulus are not adequate for long bone fixation. In order to solve this problem and still preserve the benefits of biodegradability and biocompatibility of the polymer, the concept of a total bioabsorbable fiber-reinforced composite was recently introduced. However, systems reported to date containing biodegradable in organic fibers generally lost substantial strength within a few days, suggesting the ongoing difficulty of coupling such fibers to degradable polymers. The specific aim of this proposal is to introduce the concept of surface modification for improving the interfacial bonding between the reinforced absorbable fibers and matrix in a totally absorbable composite bone fixation device. This surface treatment can also retard the hydrolytic degradation rate of the reinforcing fibers and their matrix. Such an improvement is expected to solve the major technical difficulty currently encountered in totally absorbable composite bone plates.