CERVICAL CANCER DETECTION AND SCREENING (PHASE II)

本研究的目的是开发新的和改进的诊断方法， 子宫颈癌检测和筛查仪器。 的 所采用的技术基于高分辨率数字成像 技术. 刚刚完成的一项为期5年的研究澄清并量化了， 为了细胞学自动化的目的， 传统的人类宫颈细胞学筛查，即，检测 要求巴氏涂片筛查“系统”，细胞检测 训练有素的细胞技术人员的能力，以及 这些因素。 此外，这些研究证明， 可疑和异常细胞的图像处理检测与， 或者比训练有素的细胞技术专家更好。 研究与 发展，在此（第二阶段），是进一步的具体方面， 计算机软件设计，并制定了可行的概念设计方案 诊断仪器 第二阶段开发的预期结果 将完成软件算法和其他系统参数在一个 具体设计。 这项研究的潜在商业应用是 在临床实验室仪器和测试领域。 公众 健康益处包括：（1）\准确性的潜在增加， 巴氏试验常规性能的再现性;（2）\a 从一个筛选实验室到另一个筛选实验室的标准化的可能性; 以及（3）该测试更容易可用的潜在能力 或公共有限 （三）

The objective of this research is to develop new and improved diagnostic instrumentation for cervical cancer detection and screening. The techniques employed are based upon high-resolution digital imaging technology. A 5-year study just completed has clarified and quantified, for the purposes of cytology automation, the concepts exploited in traditional human cervical cytology screening, i.e., the detection requirements of the Pap smear screening "system", the cell detection capabilities of trained cytotechnologists, and the interrelationship of these factors. In addition, these studies proved that state-of-the-art image processing detection of suspicious and abnormal cells is as good as, or better than, highly trained cytotechnologists. The research and development, herein (Phase II), is to further specific aspects of the computer software design and to develop the conceptual design of a feasible diagnostic instrument. The expected results from the Phase II development would be completed software algorithms and other system parameters in a specific design. The potential commercial application of this research is in the area of clinical laboratory instrumentation and testing. The public health benefits include: (1)\a potential increase in accuracy and reproducibility in the routine performance of the Pap test; (2)\a possibility of standardization from one screening laboratory to another; and (3)\the potential capability of a more ready availability of this test to the general public. (3)