PEPTIDE SYNTHESIZER WITH PREPARATIVE AND ANALYTICAL HPLC

需要资金来购买必要的设备，以 建立一个功能齐全的自动化多肽合成设施 肯塔基大学。该设施将并入和 完成我们的大分子结构分析核心实验室。这 实验室已经配备了目前最好的设备 用于蛋白质/多肽测序和分析以及寡核苷酸 合成和测序。目前的设备包括ABI气相 蛋白质测序仪、Beckman 6300型氨基酸分析仪和ABI 自动寡核苷酸合成仪。这些设施是唯一这样的设施 在肯塔基州和我们的200英里半径内提供 大学。因此，它们对于研究一些 NIH资助的调查人员在这个校园里，上面列出的是联合调查人员 其研究计划载于《 申请。这些独特的设施也将用作研究 为本地区科学界其他成员提供的资源 在按优先顺序、按使用收费的基础上为区域提供服务。

Funds are requested to purchase the items of equipment necessary to constitute a fully functional automated peptide synthesis facility at the University of Kentucky. This facility will be incorporated into and complete our Macromolecular Structure Analysis Core Laboratory. This laboratory is already equipped with the best currently available equipment for protein/peptide sequencing and analysis and for oligonucleotide synthesis and sequencing. Current equipment includes an ABI gas phase protein sequencer, a Beckman Model 6300 amino acid analyzer and an ABI automatic oligonucleotide synthesizer. These facilities are the only such available within the State of Kentucky and within a 200 mile radius of our University. Thus, they are essential for the studies of a number of NIH-funded investigators on this campus, listed above as co-investigators and whose research programs are set forth in the narrative portions of the application. These unique facilities will also serve as a research resource for other members of the scientific community in our geographic region on a prioritized, fee-for-use basis.