Compartmental analysis of T-cell responses in thoracic malignancies

为了改进癌症的免疫治疗，我们必须能够确定癌症患者如何“看到”突变的癌症蛋白。血液是完成这一任务的最简单、最有用的免疫杀伤细胞来源，但排出肿瘤的淋巴结和冲洗肿瘤的液体中的此类杀伤细胞数量可能比血液高得多。如果是这样的话，研究它们将有助于我们更好地跟踪治疗反应，并使我们能够选择最好的疫苗突变蛋白。

To improve immune therapy for cancer we have to be able to determine how cancer patients ‘see’ mutated cancer proteins. Blood is the easiest & most useful source of immune ‘killer’ cells for that task, but the lymph node that drains the tumour and the fluid that bathes a tumour probably contain a much higher number of these killer cells than blood. If so, studying them would help us better track responses to therapy and enable us to choose the best mutated proteins for a vaccine.