Capital funding for Helical Tomography
Capital funding for Helical Tomography
批准号:
EP/T012013/1
负责人:
James Naismith
金额:
$749.79万
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2019
资助国家:
英国
项目状态:
已结题
起止时间:
2019 至 --
中文摘要
生命科学部门构成了英国经济的关键部分:它雇佣了超过22万人,对GDP和英国的贸易平衡做出了重大贡献,对于为患者开发尖端治疗方法至关重要。它得到了英国世界领先的健康和生命科学研究基地的支持。许多关键的研究突破反过来又得益于工程和物理科学(EPS)研究的进步--这些研究提供了越来越复杂的仪器和方法,以支持对活体(从微生物到植物、动物和人体)和生物过程(包括疾病病理学和药物作用)的研究。从基础理解到应用研究再到产品开发,整个生态系统的所有部分的研发对于实现长期经济增长和农业、食品安全、医疗保健和公共卫生的持续进步至关重要。历史上的创新模式往往是线性的,带有一定程度的偶然性。如果物理学家、工程师、生命科学家和行业大规模合作,颠覆性技术和科学突破将会加速。这就是罗莎琳德·富兰克林研究所(RFI)的领域:它的联络点(Hub)设在哈威尔科学和创新园区,与英国领先高等院校的正式Spoke相联系,它将整合学术界和工业界的互补专业知识,创建一个将物理科学和生命科学结合在一起的全国卓越的方法开发中心。它将创造高价值的就业机会,保护和吸引外来投资,并推动长期增长;并为政府创新、产业和区域战略的实施做出贡献。
英文摘要
The Life Sciences sector forms a key part of the UK economy: it employs over 220,000 people, contributes significantly to GDP and UK balance of trade, and is crucial for developing leading-edge treatments for patients. It is underpinned by the UK's world-leading research base in the health and life sciences. Many key research breakthroughs are, in turn, enabled by advances in engineering and physical sciences (EPS) research - which provide ever more sophisticated instrumentation and methods to support the study of living organisms (from microbes to plants, animals and the human body) and biological processes (including both disease pathology and drug action). R&D across all parts of this ecosystem - from fundamental understanding to applied research to product development - is crucial for the delivery of long-term economic growth and continued advances in agriculture, food security, healthcare and public health. Historic models of innovation have often been linear, involving a degree of serendipity. Disruptive technologies and scientific breakthroughs will be accelerated if physical scientists, engineers, life scientists and industry work together, and at scale. This is the domain of the Rosalind Franklin Institute (RFI): with a focal point (Hub) at Harwell Science and Innovation Campus, linked to formal Spokes in leading HEIs across the UK, it will integrate complementary expertise from academia and industry to create a national centre of excellence for methods development at the convergence of the physical and life sciences.It will create high-value jobs, protect and attract inward investment, and drive long-term growth; and contribute to the delivery of the Government's innovation, industrial and regional strategies.
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Rosalind Franklin Institute Core Capital Award
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Integrating confocal microscopy and cryo plasma FIB milling for tomography
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Capital funding for NMR
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Capital funding for Spotiton
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财政年份:2019
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负责人:James Naismith
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Recurrent funding for the RFI 2019 to 2021
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财政年份:2019
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负责人:James Naismith
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The enzymatic methylation of the peptide bond
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批准号:BB/R018189/1
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负责人:James Naismith
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依托单位:
Structural Biology in the RFI
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批准号:EP/S025243/1
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资助金额:$210.18万
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财政年份:2018
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负责人:James Naismith
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依托单位:
Enhanced productivity and functionality of Modified Ribosomally Produced Peptides (M-RIPPs)
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批准号:BB/M028461/2
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财政年份:2017
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负责人:James Naismith
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依托单位:
Enhanced productivity and functionality of Modified Ribosomally Produced Peptides (M-RIPPs)
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依托单位:
The human serine palmitoyltransferase (SPT) complex; specificity, structure, regulation and inhibition
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资助金额:$11.7万
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财政年份:2015
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依托单位:
Exploring the mechanism and scope of the enzymatic formation of five membered ring
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依托单位:
13TSB_SynBio:Enhanced discovery and scalable synthesis of therapeutic cyclic peptides
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财政年份:2013
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负责人:James Naismith
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依托单位:
Elucidation of the bacterial sphingolipid biosynthetic pathway in Sphingomonas wittichii
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批准号:BB/I014632/1
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财政年份:2011
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负责人:James Naismith
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依托单位:
Conformational states of membrane proteins: Technology development for bioscience
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财政年份:2010
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负责人:James Naismith
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依托单位:
CCP4: Low resolution complexes; handling difficult data; empowering structural biologists and supporting UK structural biology
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资助金额:$10.42万
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财政年份:2008
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负责人:James Naismith
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依托单位:
CCP4 - Collaborative Computing Project in structural biology
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批准号:MC_G0900846
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资助金额:$42.22万
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财政年份:2008
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负责人:James Naismith
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依托单位:
Serine palmitoyltransferase / structure and function of the first enzyme in sphingolipid biosynthesis
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财政年份:2008
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负责人:James Naismith
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依托单位:
海外基金