CARDIOVASCULAR INTERACTIONS OF STRESS AND SALT IN THE MICROPIG

小型猪是研究长期血液动力学的良好动物模型 压力调节，因为（a）其心血管的相似性 （B）与人类的互动， 实验造成的后勤问题比灵长类动物少， 可能是攻击性的，或者是狗，它们天生就有亲和力。的技术 长期内固定患者长期心血管功能的研究 和行为的微型猪已被开发用于研究的相互作用， 压力和盐摄入量。正在调查的具体假设是， 引起呼吸抑制、心动过缓和 外周血管收缩也增加了血管内皮细胞的循环浓度。 抑制钠泵活性的内分泌因子。确认 这一假设将提供一个重要的进展， 长期血压的环境和行为因素 调控非药物性自我调节能力增强 血压可能会影响许多心血管疾病， 衰老包括中风

The micropig is an excellent animal model for study of long-term blood pressure regulation because of (a) the similarity of its cardiovascular system to man, and (b) the fact that interactions with humans during experimentation pose fewer logistical problems than either primates, who may be aggressive, or dogs, who are naturally affiliative. A technology for study of long-term cardiovascular functions in the chronically instrumented and behaving micropig has been developed for study of interactions of stress and salt intake. The specific hypothesis under investigation is that behavioral stress which evokes respiratory suppression, bradycardia, and peripheral vasoconstriction also increases circulating concentrations of an endocrine factor which suppresses sodium pump activity. Confirmation of this hypothesis would provide a significant advance concerning the role of environmental and behavioral factors in long-term blood pressure regulation. Increased ability for nonpharmacological self-regulation of blood pressure could impact on a number of cardiovascular disorders of aging, including stroke.