STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS

15年前收集的一系列血清样本来自未经治疗的 急性曼氏血吸虫病先前已经研究了 它们对不同染色体的IgG和IgE抗体应答的演变 抗原由于最近认识到IgG 4抗体的重要性， 用于诊断特异性和阻断对 寄生虫，这种独特的血清收集已被重新研究，以确定 发展特异性IgG 4抗体应答的动力学。有趣的是， 似乎在IgG 1、IgG 2和IgG 3亚类的抗体产生的同时， 在急性感染的几周内，特异性IgG 4抗体（对鸡蛋和 成虫抗原）在感染后6-9个月内不会发展。 这条信息特别令人感兴趣，因为几乎 没有其他情况下，IgG 4反应的自然发展， 人类已经被记录下来了。

Serial serum specimens collected 15 years ago from untreated patients with acute schistosomiasis mansoni have been previously studied for the evolution of their IgG and IgE antibody responses to different schistosome antigens. Because of the recently recognized importance of IgG4 antibodies both for diagnostic specificity and for blocking allergic reactions to the parasite, this unique collection of sera has been restudied to define the kinetics of a developing specific IgG4 antibody response. Interestingly, it appears that while antibodies of 1gG1, IgG2 and IgG3 subclasses develop within weeks of acute infection, specific IgG4 antibodies (to both egg and adult schistosome antigen) do not develop for 6-9 months after infection. This piece of information is of particular interest, since there are almost no other instances where the natural development of an IgG4 response in humans has been recorded.