DIABETES MELLITUS IN ALASKA NATIVES

我们建议在本港的 阿拉斯加州安妮特岛的Metlakatla印第安社区。 约1，525人 受试者居住在这个社区，其中约1，100人是Tsimshian 印第安人 临床糖尿病的初步研究 整个阿拉斯加州的患病率显示， 患病率发生在安妮特岛的阿拉斯加土著居民中。 然而，20到30年前，糖尿病在阿拉斯加很少发生。 当地人 在这段时间里，生活方式发生了很大变化， 商店购买的食品和劳动力的日益普及 拯救机器 该研究项目的初步目标将包括 测量糖尿病患病率，确定危险因素 糖尿病，以及设计一种行为干预， 降低这种代谢紊乱的患病率。 具体 目标和实现这些目标的程序将取决于 什么是被认为是可行的，对土著社区感兴趣的， 调查人员在规划过程中 目前， 本研究项目的初步设想如下。 口服 安妮特岛所有阿拉斯加原住民的葡萄糖耐量测试 年龄20岁及以上将进行。 由于年龄小， 人口结构，大约一半的安妮特岛居民将 包括在这次调查中。 将使用世界卫生组织标准 确定正常糖耐量、糖耐量受损、 耐受性和糖尿病。 我们希望所有发现的糖尿病 NIDDM，由于阿拉斯加原住民中的IDDM罕见。 空腹胰岛素和 将测量C肽水平，以评估胰岛素的患病率 葡萄糖耐量正常的受试者中的耐药性。 文书 评估饮食摄入量和身体活动将制定与帮助 合作者的。 这些生活方式变量将在受试者中进行比较 正常和异常的葡萄糖耐量，以评估其对 糖尿病患病率

We propose to plan a research project on diabetes mellitus among the Metlakatla Indian Community of Annette Island, Alaska. About 1,525 subjects reside in this community, of whom about 1,100 are Tsimshian Indians. A preliminary study performed by us of clinical diabetes mellitus prevalence across the entire state of Alaska revealed that the highest prevalence occurred among Alaska Native residents of Annette Island. Twenty to thirty years ago, however, diabetes rarely occurred among Alaska Natives. Over this time period, lifestyle has changed considerably with the increasingly widespread availability of store bought food and labor saving machines. Preliminary goals of the research project will include measurement of diabetes mellitus prevalence, ascertainment of risk factors for diabetes mellitus, and the design of a behavioral intervention to decrease the prevalence of this metabolic disorder. The specific objectives and procedures to be followed to achieve them will depend on what is deemed feasible and of interest to the Native community and investigators during the planning process. At the current time, the following tentative plan for the research project is as follows. Oral glucose tolerance testing of all Alaska Native residents of Annette Island age 20 years and older will be conducted. Due to the youthful age structure of the population, about half of Annette Island residents will be included in this survey. World Health Organization criteria will be used to assign the diagnosis of normal glucose tolerance, impaired glucose tolerance, and diabetes mellitus. We expect all diabetes found to be NIDDM, due to the rarity of IDDM among Alaska Natives. Fasting insulin and C-peptide levels will be measured to assess the prevalence of insulin resistance among subjects with normal glucose tolerance. Instruments to assess dietary intake and physical activity will be developed with the help of collaborators. These lifestyle variables will be compared in subjects with normal and abnormal glucose tolerance to assess their effect on diabetes prevalence.