AGING EFFECT ON THE IMMUNE RESPONSE

1)小鼠和人Tβ诱导的影响因素 以及免疫球蛋白D可用于增强抗体的可能性 在老年小鼠中产生，可能与IL-2结合。 老年人记忆B细胞发育及其对T细胞的调节 幼鼠将被比较(G.J.索贝克博士和R.F. Coico)。 2)表面性质、数量和功能活性 老年和幼年小鼠和人类皮肤中的朗格汉斯细胞， 以及表面抗原表达上调(特别是Ia 抗原)通过淋巴因子作用于这些细胞。它们上的Ia表达式 表皮中的抗原提呈细胞受到严重损害 年龄，这可能会影响帮助者对抑制者的平衡 T细胞对经皮肤提呈的抗原的反应 对皮肤肿瘤的反应(D.V.Belsito博士和G.J.Thobecke博士)。 3)各种T细胞的功能活性及其相互关系 衰老小鼠免疫反应中与细胞相关的亚群 曲面特性。进一步描述三个不同的 抑制子细胞的类型及计数 前体(S.R.S.Gottesman博士)。 4)老年小鼠胸腺前细胞的再生活性 这些细胞在表面上的异质性 感受器。老年小鼠胸腺功能的评价 接收和繁殖移居的原胸腺细胞(R.R. Basch)。 5)趋化反应、内皮细胞黏附 粒细胞产生杀菌氧代谢产物的研究 来自老年人的，以及淋巴因子和 腺苷对这些反应的影响与细胞膜和 细胞骨架特性(B.Cronstein和R.Hirschhorn博士)。

1) The factors influencing T delta induction in mice and humans and the possibility that IgD may be used to augment antibody production in aged mice, perhaps in combination with IL-2. Memory B cell development and its T cell regulation in aged and young mice will be compared (Drs. G.J. Thorbecke and R.F. Coico). 2) The surface properties, numbers and functional activity of Langerhans cells in the skin of aged and young mice and humans, and the upregulation of surface antigen expression (particularly Ia antigen) on these cells by lymphokines. The Ia expression on these antigen-presenting cells in the epidermis is greatly impaired with age and this may influence the balance of the helper to suppressor T cell in responses to antigen presented via skin and in the response to skin tumors (Drs. D.V. Belsito and G.J. Thobecke). 3) The functional activity and interrelation between various T cell subsets in the immune response of aged mice as related to cell surface properties. Further characterization of three different types of suppressor cells and enumeration of suppressor cell precursors (Dr. S.R.S. Gottesman). 4) The regenerative activity of prethymic cells in aged mice and the heterogeneity of these cells in terms of their surface receptors. Assessment of the ability of the thymus in aged mice to receive and propagate immigrant prothymocytes (Dr. R. Basch). 5) The chemotactic response, endothelial cell adherence, and generation of bactericidal oxygen metabolites by granulocytes from aged humans, as well as the influence of lymphokines an adenosine on these responses as related to cell membrane and cytoskeleton properties (Drs. B. Cronstein and R. Hirschhorn).