CARET--STUDY CENTER

CARET是一项正在进行的肺癌化学预防双盲试验 30 mgβ-胡萝卜素与25,000 mgβ-胡萝卜素联合使用的疗效和安全性 每天在两个高危人群中使用维甲酸棕榈酸酯：(A)男性和 女性现任和前任吸烟者主要是从保险公司招募的 来源，以及(B)有大量职业石棉接触的男性 主要从基于就业的来源招聘。我们已经记录了 成功招募，出色的依从性，并将副作用降至最低 到目前为止，超过15,000名参与者在六个研究中心随机进行了调查。穿过 1993年4月30日，Caret随机选择了4000名接触石棉的工人， 超过所有五个Caret石棉中心的应计目标，以及11,105 烟瘾很大的人。西雅图和波特兰已经超过了他们的重度吸烟者 欧文正在按部就班地在1994年7月实现其目标。在.期间 在最后五年期间，Caret将专注于保留、遵守 协议、端点的确定、关键设计参数的监控、 试验的收尾、分析和发表。预测表明 有14,240名吸烟者和4,010名接触石棉的参与者以及 114,100人年的跟踪调查，截至1998年2月，Caret将 能够检测到这两个国家的肺癌发病率降低了23% 高危人群加在一起，减少了27%、49%、32%和35% 吸烟者、女性吸烟者、男性吸烟者和接触石棉的亚组， 分别进行了分析。 纽黑文中心在年实现了随机选择1000名参与者的目标 1992年11月。截至1993年4月30日，研究中心已将 1,019名接触石棉的工人加上2名重度吸烟者配偶。参与者 将继续每年通过电话联系两次，并在 在整个随访期内，研究中心每年一次。留住努力 将在最后5年赠款期间进一步强调，包括 参与者咨询委员会和一份当地通讯。我们将参与其中 在Caret范围内的分析和出版物中。

CARET is an ongoing double-blind lung cancer chemoprevention trial of the efficacy and safety of the combination of 30 mg beta-carotene and 25,000 IU retinyl palmitate daily in two high-risk populations: (a) male and female current and former smokers recruited primarily from insurance-based sources, and (b) males with extensive occupational asbestos exposure recruited primarily from employment-based sources. We have documented successful recruitment, excellent adherence, and minimal side effects in over 15,000 participants randomized thus far at six study centers. Through 30 April, 1993, CARET has randomized 4,000 asbestos-exposed workers, exceeding accrual goals at all five CARET asbestos centers, and 11, 105 heavy smokers. Seattle and Portland have exceeded their heavy smoker goals, and Irvine is on track to achieve its goal in July 1994. During the final five-year period, CARET will focus on retention, adherence to protocol, ascertainment of endpoints, monitoring of key design parameters, closeout of the trial, and analysis and publication. Projections indicate that with 14,240 smokers and 4,010 asbestos-exposed participants and 114,100 person-years of follow-up through February 1998, CARET will be capable of detecting a 23% reduction in lung cancer incidence in the two high-risk populations combined, and 27%, 49%, 32%, and 35% reductions in the smokers, female smokers, male smokers, and asbestos-exposed subgroups, respectively. The New Haven Center met its goal of randomizing 1,000 participants in November 1992. Through 30 April, 1993 the Study Center has randomized 1,019 asbestos-exposed workers plus 2 heavy smoker spouses. Participants will continue to be contacted by telephone twice yearly and seen at the Study Center annually throughout the follow-up period. Retention efforts will be further emphasized in the final 5-year grant period, including a participant advisory committee and a local newsletter. We will participate in CARET-wide analyses and publications.