VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE

我们研究了神经递质代谢物和葡萄糖代谢。 在被监禁的暴力罪犯、纵火犯和健康志愿者中。 我们发现低位脑脊液(CSF)、5-羟基吲哚乙酸 5-HIAA浓度与口服葡萄糖时的低血糖 耐受性测试与冲动的暴力行为 和着火装置。在后续的研究中，我们发现低血压病患者 血糖最低值和低脑脊液5-HIAA浓度是强有力的预测因子 冲动的暴力罪犯和纵火犯中的累犯。我们 记录了一种深刻的昼夜活动节律紊乱 患有间歇性爆炸性精神障碍的酗酒暴力者。这个 酗酒者与低脑脊液5-HIAA相关的人格异常 暴力犯罪者被发现是慢性易怒和 精神衰弱。分子遗传学家族研究的样本采集 关于酗酒暴力犯罪者的调查已经完成。临床资料 在精神诊断和所有生化指标方面都是盲人 生理数据已输入计算机，并经过复核 对于错误。分子遗传学分析在实验室中的应用 神经化学正在进行中。

We have investigated neurotransmitter metabolites and glucose metabolism in incarcerated violent offenders, arsonists, and healthy volunteers. We have found that low cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) concentrations, and hypoglycemia during oral glucose tolerance tests are associated with each other and impulsive violent acts and fire setting. In a follow-up study, we found that a low blood glucose nadir and low CSF 5-HIAA concentration were powerful predictors of recidivism among impulsive violent offenders and fire setters. We have documented a profound disturbance of day-night activity rhythms in alcoholic violent offenders with intermittent explosive disorder. The personality abnormalities associated with low CSF 5-HIAA in alcoholic violent offenders were found to be chronic irritability and psychasthenia. Sample collection for the molecular genetic family study on alcoholic violent offenders has been completed. The clinical data have been blind rated for psychiatric diagnoses and all biochemical and physiological data have been entered in the computers and double checked for errors. Molecular genetic analyses in the Laboratory of Neurochemistry are underway.