Formation of the Chlamydial Inclusion Requires Host Trafficking Pathways

利用细胞和生化方法，本项目旨在研究病原体衣原体劫持的膜运输途径，并确定这些途径的关键成分。衣原体是导致一系列人类和动物疾病的专性细胞内病原体。为了在宿主细胞内生存，病原体劫持了宿主的膜运输途径，制造了一个称为包涵体的细胞内生态位。除了提供一个宽松的环境外，这种策略还保护病原体免受宿主免疫系统的攻击。

Using cellular and biochemical approaches this project aims to examine the membrane trafficking pathways hijacked by the pathogen Chlamydia and to define the key components of these pathways. Chlamydia are obligate intracellular pathogens responsible for a range of human and animal diseases. In order to survive within the host cell, the pathogen hijacks the host's membrane trafficking pathways to engineer an intracellular niche called an inclusion. In addition to providing a permissive environment, this strategy also shields the pathogen from the host's immune system.