COMPARATIVE MEDICINE RESEARCH CENTER

年比较医学研究中心的长期目标 密苏里大学哥伦比亚分校兽医病理学系 是促进生物医学研究的进步，从而改善 通过提高实验室的质量和清晰度实现人的条件 动物通过基础和应用生物医学研究与 实验动物医学、病理学和科学。从历史上看， 生物医学研究的进展涉及动物。动物被用来 在美国国立卫生研究院资助的所有研究中，约有一半是这样的。通过改进我们的 了解生物学、病理生理学、疾病和研究 使用动物‘试剂’对动物进行更有意义的推断 人类健康和疾病的衍生数据将成为可能。我们的特定 目标包括：1)有重点的调查，以提供了解和 对影响使用的主要当代问题的可能解决办法 研究中的动物；2)通过 适当的出版物和演示文稿；以及3)协助 应用我们的研究成果。另一个目标是提供研究 提供培训机会，并鼓励在广泛领域开展教育 实验动物学。 我们已经确定了影响动物使用的六个主要问题 研究，在这份提案中，我们提出了研究项目的设计 他们在以下项目标题下的研究： --啮齿动物孤儿路径病毒：分子特征和 诊断试剂的研究进展 --啮齿动物孤儿致病机理及其与研究的关系 --猪肠道节段丝状细菌的生物学 啮齿动物 --生产用作诊断试剂的特定病毒抗原 使用杆状病毒表达系统 --病毒基因扩增试验检测小鼠体内病毒 生物样本 纤毛相关呼吸道芽孢杆菌感染的发病机制

The long-term objective of the Comparative Medicine Research Center in the Department of Veterinary pathology at University of Missouri-Columbia is to enhance advances in biomedical research and thereby improve the human condition by improving the quality and definition of laboratory animals through basic and applied biomedical research related to laboratory animal medicine, pathology, and science. Historically, progress in biomedical research has involved animals. Animals are used in about half of all research funded by the NIH. By improving our understanding of the biology, pathophysiology, diseases, and research uses of the animal 'reagent' more meaningful extrapolation of animal derived data to human health and disease will be possible. Our specific aims include: 1) focused investigations to provide understanding and possible solutions to major contemporary problems affecting the use of animals in research; 2) dissemination of this information through appropriate publications and presentations; and 3) to assist in the application of our research findings. Another aim is to provide research training opportunities and to encourage education in the broad area of laboratory animal science. We have identified six major problems that affect the use of animals in research and in this proposal we present designs of research projects for their study under the following project titles: -- Rodent Orphan Pathoviruses: Molecular Characterization and Development of Diagnostic Reagents -- Rodent Orphan Pathoviruses: Pathogenesis and Interface with Research -- The biology of the Intestinal, Segmented, Filamentous Bacteria of Rodents -- Production of Specific Viral Antigens for Use as Diagnostic Reagents Using a Baculovirus Expression System -- Viral Gene Amplification Assays of detection of Murine Viruses in Biological Samples --Pathogenesis of Cilia-Associated Respiratory Bacillus Infection