CARET--STUDY CENTER

CARET是一项正在进行的双盲肺癌化学预防试验， 30毫克β-胡萝卜素和25，000毫克β-胡萝卜素的组合的有效性和安全性 在两个高危人群中每日给予棕榈酸视黄酯IU：（a）男性和 主要从保险公司招募的女性现吸烟者和前吸烟者 来源，和（B）男性与广泛的职业石棉暴露 主要从就业来源招聘。我们记录 成功招募，良好的依从性，以及最小的副作用， 到目前为止，超过15，000名参与者在六个研究中心随机分组。通过 1993年4月30日，CARET随机抽取了4，000名接触石棉的工人， 超过了所有五个CARET石棉中心的应计目标， 烟瘾很大。 西雅图和波特兰的吸烟人数已经超过了他们的重度吸烟者 目标，欧文是在轨道上实现其目标在1994年7月。期间 在最后五年期间，CARET将专注于保留，遵守 协议，确定端点，监控关键设计参数， 试验结束、分析和发表。预测表明 有14,240名吸烟者和4,010名石棉接触者， 到1998年2月，对114，100人-年的随访， 能够检测到两个国家肺癌发病率降低23%， 高风险人群合并，分别减少27%、49%、32%和35%， 吸烟者、女性吸烟者、男性吸烟者和接触石棉的亚组， 分别 纽黑文中心实现了随机抽取1,000名参与者的目标， 1992年11月截至1993年4月30日，研究中心已随机 1，019名接触石棉的工人加上2名重度吸烟者配偶。参与者 将继续每年两次通过电话联系， 在整个随访期间，研究中心每年进行一次。留用工作 将在最后5年的资助期内进一步强调，包括 参与者咨询委员会和当地时事通讯。我们将参加 在CARET范围内的分析和出版物中。

CARET is an ongoing double-blind lung cancer chemoprevention trial of the efficacy and safety of the combination of 30 mg beta-carotene and 25,000 IU retinyl palmitate daily in two high-risk populations: (a) male and female current and former smokers recruited primarily from insurance-based sources, and (b) males with extensive occupational asbestos exposure recruited primarily from employment-based sources. We have documented successful recruitment, excellent adherence, and minimal side effects in over 15,000 participants randomized thus far at six study centers. Through 30 April, 1993, CARET has randomized 4,000 asbestos-exposed workers, exceeding accrual goals at all five CARET asbestos centers, and 11, 105 heavy smokers. Seattle and Portland have exceeded their heavy smoker goals, and Irvine is on track to achieve its goal in July 1994. During the final five-year period, CARET will focus on retention, adherence to protocol, ascertainment of endpoints, monitoring of key design parameters, closeout of the trial, and analysis and publication. Projections indicate that with 14,240 smokers and 4,010 asbestos-exposed participants and 114,100 person-years of follow-up through February 1998, CARET will be capable of detecting a 23% reduction in lung cancer incidence in the two high-risk populations combined, and 27%, 49%, 32%, and 35% reductions in the smokers, female smokers, male smokers, and asbestos-exposed subgroups, respectively. The New Haven Center met its goal of randomizing 1,000 participants in November 1992. Through 30 April, 1993 the Study Center has randomized 1,019 asbestos-exposed workers plus 2 heavy smoker spouses. Participants will continue to be contacted by telephone twice yearly and seen at the Study Center annually throughout the follow-up period. Retention efforts will be further emphasized in the final 5-year grant period, including a participant advisory committee and a local newsletter. We will participate in CARET-wide analyses and publications.