PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS OF ABUSE IN HAIR

通过多种方法在人发标本中检测到药物残留 分析技术。 这些报告引起了极大的兴趣 用头发作为药物使用的历史记录 目前的研究是 目的是确定药物滥用的存在和时间进程， 人的头发 有化学物质滥用史的健康男性志愿者 参与了这项研究。 获得了知情同意书，所有 该程序由医院机构审查委员会批准。 受试者居住在ARC的临床病房。 头部和面部毛发 在给药前和给药后采集样本， 虐待 还采集了血液、唾液和尿液标本。 分析 通过放射免疫测定法进行组织和生物流体的药物测定， 气相色谱/质谱 这些研究为确定 头发作为药物滥用的“历史记录”的有用性。

Drug residues have been detected in human hair specimens by a variety of analytical techniques. These reports have generated substantial interest in using hair as a historical record of drug usage. Current studies are designed to determine the presence and time course of drugs of abuse in human hair. Healthy male volunteers with a history of chemical substance abuse participated in the study. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. Subjects resided on the clinical ward of the ARC. Head and facial hair specimens were obtained prior to and after administration of drugs of abuse. Blood, saliva and urine specimens also were obtained. Analyses of tissue and biofluids for drug was performed by radioimmunoassay and gas chromatography/mass spectrometry. These studies provide the scientific basis for determination of the usefulness of hair as a "historical record" for substance abuse.