PHARMACOKINETICS AND PHARMACODYNAMICS OF OPIATE ANALGESICS

单次给药的药代动力学和药效学效应 肠胃外给药的鸦片制剂（海洛因，吗啡，氢吗啡酮， 可待因、羟考酮、羟吗啡酮和舌下丁丙诺啡） 研究了 比较血液和唾液中的药物浓度 药理作用。 此外，该研究的目的是 确定是否可以在尿液中发现海洛因滥用的代谢标志物 和其他生物液体。 受试者为有海洛因滥用史的健康男性。 知情 获得同意书，所有程序均得到医院批准 机构审查委员会。 总共三个测试剂量（安慰剂和两个 活性剂量）以随机顺序给药。 采取了试验措施 24小时，并收集生物流体7天后， test. 通过以下方法分析生物流体中的药物和代谢物： 色谱和免疫测定技术。 本研究的意义在于药物的表征， 代谢物随时间的出现和消失及其关系 药物引起的影响。 这也是我们继续寻找代谢物 海洛因和其他阿片类药物在尿液，唾液和其他 生物样本

The pharmacokinetic and pharmacodynamic effects of single doses of parenterally administered opiates (heroin, morphine, hydromorphone, codeine, oxycodone, oxymorphone and sublingual buprenorphine) were studied. Concentrations of drug in blood and saliva levels were compared to pharmacologic effects. Additionally, the study was performed to determine if a metabolic marker for heroin abuse could be found in urine and other biological fluids. The subjects were healthy males with a history of heroin abuse. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. A total of three test doses (placebo and two active doses) were administered in random order. Test measures were made for 24 hours and biological fluids were collected for 7 days after each test. The biological fluids were analyzed for drug and metabolites by chromatographic and immunoassay techniques. The significance of this study lies in the characterization of drug and metabolites appearance and disappearance over time and their relationship to drug-induced effects. Also, this continues our search for metabolite markers for heroin and other opiates in urine, saliva and other biological samples.