COCAINE AND MARIJUANA USE DURING PREGNANCY AND PREGNANCY OUTCOME

非法药物使用与妊娠结局之间的关系一直是 有争议的。自我报告的药物使用是出了名的不准确，而且 血液和/或尿液的选择性筛查往往会导致偏见 确定药物使用情况，因为筛查的原因可能同样重要 作为危险因素的药物使用本身。有几个系统化的 一项关于孕期特定时间用药的大规模研究 确定的女性队列，收集了详细数据的更少 不良妊娠结局的其他危险因素。在这个项目中， 从大约7500名妇女进入阴道时获得的血清 对感染和早产儿研究(23-26周)进行大麻筛查 和可卡因代谢物。此外，在分娩时获得的血清低 对足月儿的出生体重、早产儿和随机抽样进行筛查，如 血清是在31-36周时从无并发症的随机样本中获得的 妊娠和从经历胎盘早剥的妇女获得的血清 和前置胎盘。收集的阴道感染和怀孕研究 关于各种混杂变量的大量数据，并使大多数 对可卡因和大麻使用的影响的彻底分析 妊娠结局。

The relationship between illicit drug use and pregnancy outcome has been controversial. Self-reported drug use is notoriously inaccurate, and selective screening of blood and/or urine often results in biased ascertainment of drug use, as the reason for screening may be as important a risk factor as the drug use itself. There have been a few systematic large-scale studies of drug use at specified times during pregnancy in a defined cohort of women, and even fewer that have collected detailed data on other risk factors for adverse pregnancy outcome. In this project, serum obtained from approximately 7,500 women on entry to the Vaginal Infections and Prematurity Study (23-26 weeks) were screened for marijuana and cocaine metabolites. In addition, serum obtained at delivery of low birth weight, preterm and a random sample of term infants was screened, as was serum obtained at 31-36 weeks from a random sample of uncomplicated pregnancies and serum obtained from women experiencing abruptio placenta and placenta previa. The Vaginal Infections and Pregnancy Study collected extensive data on a variety of confounding variables, and enabled the most thorough analysis yet of the effect of cocaine and marijuana use on pregnancy outcome.