ROLE OF NEUROPEPTIDES AND BIOGENIC AMINES IN NEUROENDOCRINE REGULATION

血管紧张素II受体： 血管紧张素II通过AT2受体调节脑血流量。这个 选择性配体PD 123319和CGp 42112作为激动剂 自动调节倾向于更高的血压。行政管理 PD 123319可提高卒中沙土鼠模型的存活率。 脑血管AT2受体降低cGMP及其刺激作用 收缩离体鼠的基底动脉。 血管紧张素(3-8)(血管紧张素IV)的应用改善 出血后脑血管血流。一种新的放射性配体[125I]CGP 42112，已经被用来量化和表征大脑AT2受体。 视觉系统(上丘)中的AT1和AT2受体 由视神经传入调节。去神经后， AT2表达减少，AT1受体表达增加。 AT2受体已从新生大鼠中纯化为均一 肾经增溶、凝胶过滤、亲和层析。 颈动脉和主动脉球囊损伤后AT1的高表达 受体仅限于新生内膜中的增殖细胞。 生殖激素(雌激素-孕激素)调节其表达。 AT1受体在背弓状核中的分布。 AT1受体在小鼠乳腺导管肿瘤中的高表达 起源，而AT2受体与结缔组织相关 起源于小叶的肿瘤。 未成熟的肾小球表达AT2受体；完全功能， 血管小球表达AT1受体。 其他受体： 与大鼠脑动脉褪黑激素受体的结合是敏感的 到鸟嘌呤核苷酸。刺激这些受体抑制cAMP 制作。 颈动脉内皮源性内皮素受体表达增强 气球受伤。

Angiotensin II receptors: Angiotensin II regulates cerebral blood flow through AT2 receptors. The selective ligands PD 123319 and CGP 42112 act as agonists and shift the autoregulation curves towards higher blood pressures. Administration of PD 123319 improves survival in the gerbil model of stroke. Cerebrovascular AT2 receptors reduce cGMP, and their stimulation constricts the isolated rat basilar artery. Angiotensin (3-8) (angiotensin IV) administration improves cerebrovascular flow after hemorrhage. A new radioligand, [125I]CGP 42112, has been used to quantify and characterize brain AT2 receptors. AT1 and AT2 receptors in the visual system (superior colliculus) are modulated by the optic nerve afferents. After denervation, the expression of AT2 is decreased, and that of AT1 receptors is increased. AT2 receptors have been purified to homogeneity from the neonatal rat kidney by solubilization, gel filtration, affinity chromatography. After balloon-injury of the carotid and aorta, high expression of AT1 receptors is restricted to the proliferating cells in the neointima. Reproductive hormones (estrogen-progesterone) regulate the expression of AT1 receptors in the dorsal arcuate nucleus. AT1 receptors are highly express in mice breast tumors of ductal origin, whereas AT2 receptors associate with connective tissue in tumors of lobular origin. Immature kidney glomeruli express AT2 receptors; fully functional, vascular glomeruli express AT1 receptors. Other receptors: Binding to melatonin receptors in rat cerebral arteries is sensitive to guanine nucleotides. Stimulation of these receptors inhibits CAMP production. Endothelin receptor expression is enhanced in carotid artery after balloon injury.