NEUROPHYSIOLOGICAL ABNORMALITIES--SENSORY GATING PHENOTYPES

两种神经生理学异常，门控缺陷 条件反射中的听觉诱发电位P50波 测试范式与顺畅追踪眼球运动的缺陷 (SPEM)，在精神分裂症患者和他们的 亲戚。本项目的主要目标是与 项目2的目的是确定这两个神经生理学 异常代表基因或基因的表型表达 传递精神分裂症风险的基因。多代人 包括精神分裂症先驱在内的家庭，在犹他州招募， 将对这两种异常情况进行评估。神经生理学 然后使用互补DNA对表型进行基因分型 技术，以确定其中一个或两个度量是否可以链接 与特定的遗传位点有关。P50门控和SPEM的缺陷是 两者都被认为是感官门控问题的例子 这似乎是精神分裂症的精神病理学的基础。 然而，对神经生物学的全面理解 感觉门控尚未实现。项目3的目标 是描述实验室中P50门控的神经生物学 动物模型。因为对神经生物学的更好描述是 项目1将确定更好的感官测量 可以将门控添加到P50门控和SPEM测量中 当前使用。我们在项目1中的总体目标是演示 准确地说，该基因的表型表达尽可能 传递精神分裂症遗传风险的基因。

Two neurophysiological abnormalities, a deficit in the gating of the auditory evoked potential wave P50 in the conditioning- testing paradigm and a deficit in smooth pursuit eye movements (SPEM), are frequently found in both schizophrenics and in their relatives. The principal aim of this Project, in conjunction with Project 2, is to determine if these two neurophysiological abnormalities represent phenotypic expressions of the gene or genes which convey risk for schizophrenia. Multigenerational families including schizophrenic probands, recruited in Utah, will be evaluated for both abnormalities. The neurophysiological phenotypes will then be genotyped using complementary DNA techniques, to determine if either or both measures can be linked to specific genetic loci. Deficits in P50 gating and SPEM are both thought to be examples of the problems in sensory gating which seem to underlie the psychopathology of schizophrenia. However, a comprehensive understanding of the neurobiology of sensory gating has not yet been achieved. The goal of Project 3 is to describe the neurobiology of P50 gating in laboratory animal models. As better descriptions of the neurobiology are obtained, Project 1 will determine if better measures of sensory gating can be added to the P50 gating and SPEM measurements in current use. Our overall goal in Project 1 is to demonstrate as precisely as possible the phenotypic expression of the gene of genes which convey genetic risk for schizophrenia.