CEREBRAL ISCHEMIA AND EDEMA--BIOGENIC AMINES

单胺代谢途径变化的相关性 （多巴胺和5-羟色胺）与线粒体酶系统 它们参与了自由基的产生和清除 在多巴胺代谢和水肿形成的过程中， 沙鼠双侧脑缺血。结果提示 多巴胺衍生的自由基不太可能参与脑水肿 在早期回流中，由于H_2O_2 ~产生反应之间的不平衡， 多巴胺代谢和线粒体抗氧化能力并不 在沙鼠双侧缺血15分钟后1小时再流之前发生。 然而，这项研究的结果加强了5- 羟色胺在缺血性脑水肿形成中的作用。

The association of changes in the metabolic pathway of monoamines (dopamine and 5-hydroxy-tryptamine) with mitochondrial enzyme systems which are involved in the production and removal of free radicals formed during dopamine metabolism and formation of edema was investigated in bilateral brain ischemia in gerbils. The results suggest that the involvement of dopamine-derived free radicals in brain edema is unlikely in early reflow, because imbalance between H2O2~producing reactions of dopamine metabolism and mitochondrial antioxidative capacity does not occur prior to 1 hr reflow after 15 min of bilateral ischemia in gerbils. However, the findings of this study reinforce the participation of 5- hydroxytryptamine in the formation of ischemic brain edema.